摘要
目的和方法：观察了碱性成纤维细胞生长因子（ｂＦＧＦ）对异丙肾上腺素（ｉｓｏｐｒｏｔｅｒｅｎｏｌ，ＩＳＯ）引起的大鼠心肌坏死的拮抗作用及其机制。结果：ｂＦＧＦ明显减轻了ＩＳＯ引起的大鼠心肌坏死的程度，血浆ＬＤＨ、ＭＤＡ及心肌ＭＤＡ水平比单纯ＩＳＯ组动物分别降低２４８％、３２８％及２００％（Ｐ＜００１）；心肌胶原及心肌细胞线粒体钙含量分别降低１８２％及２０８％（Ｐ＜００５）；心肌ＡＴＰ含量增加３６７％（Ｐ＜００１）。结论：ｂＦＧＦ对ＩＳＯ引起的大鼠心肌坏死具有明显的保护作用，其机制与抗脂质过氧化及心肌细胞内钙超载有关。
AIM and METHOD:The effect of basic fibroblast growth factor (bFGF) on myocardial necrosis induced by isoproterenol(ISO) in rats was observed. RESULTS:bFGF apparently decreased ISO-induced myocardial necrosis, plasma LDH,MDA and myocardial MDA levels were less than those of ISO group by 24 8%, 32 8% and 20 0% respectively ( P <0 01). The collagen and mitochondrion calcium concentration in myocardium reduced by 16 9% and 20 6% respectively( P <0 01); Myocardial ATP content increased by 36 7%( P <0 01). CONCLUSION:bFGF may play an important protective role against myocardial injury induced by ISO, which mechanism is related with preventing lipid peroxide and calcium overload in myocardial cells.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第3期203-205,共3页
Chinese Journal of Pathophysiology
基金
国家自然科学基金
关键词
异丙肾上腺素
心肌坏死
大鼠
BFGF
Fibroblast growth factor
basic
Isoproterenol
Myocardium
Necrosis
Rats
