摘要
研究微波固化保肢术提高患者生存率的免疫学机制。方法：应用色散比浊法检测患者血清Ｃ３、Ｃ４含量，应用红细胞Ｃ３ｂ受体花环（Ｃ３ｂＲＲ）、免疫复合物花环（ＣＩＣＲＲ）及直接肿瘤花环（ＴＲＲ）检测红细胞免疫功能。结果：２０例微波固化保肢组患者及２０例截肢组患者术前Ｃ３ｂＲＲ、ＴＲＲ降低，ＣＩＣＲＲ升高（Ｐ＜０．０５），Ｃ３、Ｃ４变化不明显；术后１４天时，微波组较截肢组Ｃ３ｂＲＲ、ＴＲＲ升高（Ｐ＜０．０５），ＣＩＣＲＲ变化不明显，２８天时两组各项指标恢复正常（Ｐ＜０．０５）。结论：微波固化保肢术可提高患者的红细胞免疫功能。
Objective: To observe the effect of limb -salvage and microwave tissue coagulation(MTC) on immune function in patients with osteogenic sarcoma. Methods: The erythrocyte immune func-tion of osteogenic sarcoma patients was tested with C3b receptor rosette (C3bRR) , red blood cell immunecomplex rosette (CICRR) and tumor cell red blood cell rosette (TRR) . The serum C3, C4 contents wereexamined by chromatic dispersing turbidity method. Results: In all patients C3bRR and TRR declinedmarkedly, while CICRR elevated ( P<0.05). No significant changes of C3, C4 were observed. On thefourteenth postoperative day , the C3bRR, TRR in the MTC group elevated higher than those in the amputa-tion group (P<0.05), but no prominent change of CICRR was seen. On the 28th postoperative day,all the data of these two groups returned normal (P<0.05) . Conclusion: Limb - salvage in conjunc-tion with microwave coagulation may enhance the immune function of the patients with osteogenic sarco-ma.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1999年第3期176-177,共2页
Chinese Journal of Clinical Oncology
基金
全军九五重点课题基金
关键词
成骨肉瘤
红细胞免疫
骨肿瘤
微波固化
保肢术
Osteogenic sarcoma ,Microwave ,Limb-salvage ,Etythrocyte ,Immune function
