重组人脑利钠肽治疗心血管疾病研究进展被引量：37

Progress of Recombinant Human B-type Natriuretic Peptide in Treating Heart and Vascular Diseases

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摘要重组人脑利钠肽是模拟内源性B型钠尿肽发挥生理作用的。近年的研究证实,重组人脑利钠肽治疗成人急性心力衰竭是安全、有效、耐受性好的;静脉注射重组人脑利钠肽能迅速降低急性心力衰竭患者的肺毛细血管楔压,缓解呼吸困难症状,改善预后。研究发现,重组人脑利钠肽还能减轻心肌梗死后心室重构,减轻婴儿和儿童心力衰竭,降低肺动脉高压,缓解心脏移植等待期患儿的病情。 The recombinant human B-type natriuretic peptide produces physiological effects by imitating endogenous B-type natriuretic peptide.According to recent research,the recombinant human B-type natriuretic peptide is safe and effective in treating acute heart failure.Intravenous recombinant human B-type natriuretic peptide can quickly degrade pulmonary capillary wedge pressure,relieve dyspnea,and improve a patient＇s prognosis.Some research has found that the recombinant human B-type natriuretic peptide can also degrade ventricular remodeling that occurs after myocardial infarct,relieve heart failure symptoms in infants and children,and degrade pulmonary artery hypertension.

作者李文安杨宇

机构地区中南大学湘雅二医院老年科

出处《心血管病学进展》 CAS 2010年第4期606-608,共3页 Advances in Cardiovascular Diseases

关键词重组人脑利钠肽心力衰竭肺动脉高压心血管病 recombinant human B-type natriuretic peptide heart failure pulmonary artery hypertension cardiovascular diseases

分类号 R54 [医药卫生—心血管疾病] Q516 [生物学—生物化学]

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参考文献14

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