摘要
目的 研究宫颈病理结果正常而高危型人乳头状瘤病毒（HPV）检测阳性的妇女HPV感染的自然清除情况.方法 选取2006年8月至2008年8月于上海市长宁区妇幼保健院门诊行高危型HPV检测结果阳性、而宫颈病理检查结果为正常的妇女,随访HPV感染状态（随访时间中位数为11.6个月）,分析HPV感染自然清除所需的时间及相关影响因素.结果 入选本研究的妇女共172例,平均年龄（34±10）岁（18～62岁）;随访过程中有107例（62.2%,107/172）HPV感染自然清除,总体HPV感染自然清除时间的中位数为11.3个月（95%CI为10.6～16.6个月）.不同年龄组中,〈30岁、30～39岁、40～49岁、〉49岁妇女HPV感染清除时间的中位数分别为11.3、12.0、10.9和8.5个月,4者比较,差异无统计学意义（P=0.384）.HPV感染自然清除妇女的病毒相对拷贝数中位数为22.6,HPV持续阳性者为95.0,两者比较,差异无统计学意义（P=0.061）.结论 宫颈病理结果正常且高危型HPV检测阳性的妇女在无临床干预的情况下,大部分的HPV感染能自然清除,年龄、病毒拷贝数对HPV感染自然清除无明显影响.
Objective To study the clearance of high risk human papillomavirus（HPV）infection among the women with normal cervical pathologic diagnosis.Methods One hundred and seventy.two HPV-positive cases with normal cervical pathologic diagnosis were enrolled in the study.The infection status of HPV was monitored during follow-up from Aug 2006 to Aug 2008.The time of HPV infection spontaneous clearance,as well as effect factors,were analyzed.Results During follow-up,there were 62.2%（107 cases,107/172） of the HPV infection cleared.The medium clearance time was 11.3 months（95% CI：10.6-16.6 months）.The medium clearance time of aged〈30 years,30-39 years,40-49 years and〉49 years were 11.3,12.0,10.9 and 8.5 months.respectively.There were not significant difference among aged intervals （P=0.384）.The virus copies of HPV-clearance cases and persistent-infection were 22.6 and 95.0,respectively.There was not significant difference between groups（P=0.061）.Conclusions Most of the high risk HPV infection with normal cervical pathologic diagnosis would spontaneously cleared.Age and HPV copies may play little role in the HPV clearance.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2010年第7期515-518,共4页
Chinese Journal of Obstetrics and Gynecology
