摘要
酸碱解离常数是联系溶解度与ｐＨ值之间的重要理化常数。ＴｈｅＭｅｒｃｋＩｎｄｅｘ１１ｔｈＥｄ．（１９８９）未收载有甲硝唑的该数据。用等摩尔分光光度法测定甲硝唑原料药物在ｐＨ缓冲溶液中的碱性解离常数，由公式ｐＫｂ＝ｐＫω－ｐＨ＋ｌｇ（Ａｉ－ＡＢＨ＋）／（ＡＢ－Ａｉ）计算得到ｐＫｂ为１１．４７。
Equimolar metronidazole solutions in different pH buffers were prepared. The pH value and absorbance(A) of each solution were detected. From the formula pK b=pK ω-pH+lg(A i-A BH + )/(A B-A i), the dissociation constant of metronidazole was calculated. The pK b was 11.47.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1999年第1期9-10,共2页
West China Journal of Pharmaceutical Sciences
