摘要
分别应用双抗体夹心法和流式细胞术测定52例胃癌病人的血清可溶性白细胞介素2受体(Soluble inter-leukin2 receptor,SLI-2R)和外周血CD_4/CD_8,结果胃癌病人SIL-2R明显升高,CD_4/CD_8明显降低(均P<0.01),且临床分期越高越明显,两者之间存在明显的负相关关系(r=-0.87),提示胃癌病人细胞免疫功能抑制。
Using by sandwich ELISA with monoclonal and polyclonal antibodies and cytometry analy-sis techniques. The serum soluble interleukin 2 receptor (SIL-2R) and CD4/CD8 are measured in 52 pa-tients with gastric cancer. The results show the level of SIL-2R is obvious higher than that of the healthy controls. CD4/CD8 is marked lower than that of normal group (P<0.01). There is a close negative corre-lation between SIL-2R and CD4/CD8(r =- 0.87). Those results indicate that the measurement of SIL-2R and CD4/CD8 may be a important parameter for estimating of degree of seriousness and prognosis of gastric cancer.
出处
《临床消化病杂志》
1999年第1期5-6,共2页
Chinese Journal of Clinical Gastroenterology
关键词
胃肿瘤
T淋巴细胞亚群
SIL-2R
Stomach neoplasmas Soluble interleukin 2 receptor T lymphocyte subsets
