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CD44v6和PCNA在皮肤鳞状细胞癌中的表达及其临床意义 被引量：1

Expression of CD44v6 and PCNA in human cutaneous squamous cell carcinoma and its clinical significance
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摘要 目的 :　研究CD4 4v6和PCNA与皮肤鳞状细胞癌 (SCC)临床病理特征的关系。方法 :　免疫组化法研究 4 8例SCC原发灶、11例淋巴结转移灶和 10例正常皮肤组织中CD4 4v6和PCNA的蛋白表达。结果 :　SCC标本中 ,CD4 4v6表达下调 (P <0 .0 1) ,分化越差下调越明显 (P <0 .0 5 ) ;PCNA表达增高 (P <0 .0 5 ) ,分化越差增高越明显 (P <0 .0 1)。二者与临床分期、淋巴结转移及发病部位均无关 (P >0 .0 5 ) ,且CD4 4v6和PCNA的表达无相关性 (r=- 0 .176 ,P >0 .0 5 )。结论 :　CD4 Objective: To determine the correlation between the expressions of CD44v6 and PCNA, and the clinical and pathological characteristics of human cutaneous squamous cell carcinoma (SCC).Methods: The expressions of CD44v6 and PCNA protein in 48 specimens from primary lesions of SCC, 11 metastatic lymph nodes and 10 normal skin samples were measured using immunohistochemistry method. Results: The expression of CD44v6 was down-regulated in SCC (P<0.01). The poorer the differentiation, the lower the level of the expression was (P<0.05). However, the expression of PCNA was up-regulated (P<0.05), the poorer the differentiation, the higher the expression was (P<0.01). There were no correlations with clinical stages, location of the lesion and metastasis (P>0.05), and the expressions of CD44v6 and PCNA were not correlated as well (r=-0.176,P> 0.05). Conclusion:CD44v6 and PCNA can all be used as the independent biological markers for the occurrence and development of SCC.
作者 李慧忠 樊翌明 李顺凡 吴国凤 吴志华
机构地区 广东省清远市人民医院皮肤科 广东医学院附属医院皮肤性病研究所
出处 《中国麻风皮肤病杂志》 北大核心 2004年第1期1-3,共3页 China Journal of Leprosy and Skin Diseases
关键词 CD44V6 PCNA 皮肤鳞状细胞癌 病理特征 免疫组织化学 增殖细胞核抗原 squamous carcinoma Cell CD44v6 immunohistochemistry
分类号 R739.5 [医药卫生—肿瘤]
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参考文献11

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同被引文献15

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中国麻风皮肤病杂志
2004年 第1期

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