摘要
目的：探讨青蒿提取物抗内毒素作用。方法：测定大鼠肝线粒体ＬＰＯ、溶酶体ＡＣＰ、血浆内毒素和ＴＮＦα、肝微粒体Ｐ４５０浓度、肝线粒体ＳＯＤ活性，观察小鼠死亡率和组织形态。结果：青蒿提取物、青蒿素可降低ＬＰＯ，ＡＣＰ，内毒素，ＴＮＦα，Ｐ４５０浓度，升高ＳＯＤ活性，降低内毒素休克小鼠的死亡率，延长小鼠的平均生存时间，对肝、肺组织形态也有一定的保护作用。结论：青蒿提取物具有抗内毒素作用。
Objective:To explore the antiendotoxin effect of extracts from Artemisia annua(AA) and qinghaosu(QHS).Method:LPO and SOD in chondriosome,ACP in lysosomes,tumor nicrosis factor α(TNF α) and endotoxin in plasma,and P 450 concentration in hepatic microsome of rats were determined.Mortality of endotoxemic mice and histomorphology were observed.Result:LPO,ACP,endotoxin,TNF α and P 450 content were decreased with AA and QHS.SOD activity was increased with AA and QHS.At the same time,mortality was decreased.Histomorphology of lysosomes and chondriosome of rats were protected from endotoxin.Conclusion:AA and QHS possess an antiendotoxin effect .
出处
《中国中药杂志》
CAS
CSCD
北大核心
1999年第3期166-171,共6页
China Journal of Chinese Materia Medica
