摘要
BALB/C小鼠注射柯萨奇B3病毒(CVB3m)后,第2天出现病毒血症,并从心肝肾脑等脏器分离出病毒,肝组织呈肝炎或重症肝炎病理图象,第5天抗体产生,病毒血症终止,除心脏外,其它脏器中病毒消失。病理检查可见心肌坏死,第8,9天,心肌坏死达高峰,心肌内病毒、循环抗体消失。心肌超微结构显示线粒体、心肌纤维、心肌组织等进行性病变。89%(54/63)的小鼠种毒后第3天开始出现心电图改变,主要表现在P波倒置,QRS时间延长,房室传导阻滞和出现异常Q波。心电图检测的成功,对利用动物模型进行致病机理、免疫,药物治疗等研究提供了方便。
On day 2 post-inoculation with coxsackievirus B3m (CVB3m), BALB/C mice developed viremia and the virus could be isolated from heart, liver, kidneys and brain. Histopathological changes of hepatitis and fulminant hepatitis could be seen. On day 5, anti-CVB3m neutralizing antibodies were produced and viremia disappeared. Except in heart, the virus in the other organs also disappeared. Necrotic myocytes could be seen on pathological examination. Around days 8—9, the necrosis of myocytes developed to the maximum degree. The virus in the heart as well as circulating antibodies disappeared. The ultrastructure of myocytes showed progressive changes in mitochondria, myofibrils, and the heart tissue. On day 3 post-inoculation, 89% (54/63 of the mice had alterations in ECG, mainly reverse of P wave (or QS wave) and conduction block between atria and ventricle. The use of ECG in animal model could facilitate the study of pathogenesis, immunology and chemotherapy.
出处
《上海第二医科大学学报》
CSCD
1990年第1期16-22,共7页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
心肌炎
病毒
心电图
超微结构
animal model myocarditis coxsackievirus B3m electrocardiogram
