摘要
[目的]研究犊牛脾脏提取物的体内抗肿瘤活性。[方法]采用超滤和离心技术制备脾脏提取物,选取移植型S180荷瘤小鼠为动物模型,腹腔注射脾提取物,观察小鼠存活时间,并计算抑瘤率。[结果]脾脏提取物显著增加S180荷瘤小鼠的存活率,并抑制肿瘤的生长,治疗第15天,最高抑瘤率达到61%。[结论]脾脏提取物是一种分子量小且安全有效的抗肿瘤活性物质。
[Objective] To study the antitumor activity of the extract from calf spleen in vivo.[Method] The spleen extract was prepared with technologies of ultrafiltration and centrifugation.S180-bearing mice act as animal models that were treated with intraperitoneal injection of the extract,and survival time of mice was observed and inhibition rate was calculated.[Result]The spleen extract significantly prolonged the survival period of the S180-bearing Kunming mice and inhibited the growth of S 180-cells.The tumor inhibition rate was up to 61%.[Conclusion] The spleen extract is a safe,effective and low molecular weight tumor suppressor.
出处
《安徽农业科学》
CAS
北大核心
2010年第16期8460-8461,共2页
Journal of Anhui Agricultural Sciences
关键词
犊牛
脾脏
低分子抑瘤物
抗肿瘤作用
Salf
Spleen
Low molecular weight tumor suppressor
Antitumor effects
