摘要
目的：考察唾液与血浆中核黄素药时曲线的相关性。方法：成人口服核黄素片后，用荧光分光光度法测定唾液中的核黄素，其激发波长为４７５．４ｎｍ，发射波长为５２４．７ｎｍ。结果：核黄素的回收率可达９６％，其线性范围为５ｎｇ·ｍｌ－１～３μｇ·ｍｌ－１，检出限量为５ｎｇ·ｍｌ－１，回归方程为△Ｆ′＝０．１１６ｃ＋０．２３２，ｒ＝０．９９９９。结论：测得唾液中核黄素药时曲线与文献报道的血浆药时曲线形状相似。
OBJECTIVE:To observe the correlation of concentration time curves of riboflavin in salive and plasma.METHOD: After peple orally taking riboflavin tablets,the riboflavin in salive was determinated by fluorescence spectrophotometry with excitation wavelength 475.4nm and emission wavelength 524.7nm.RESULTS:The recovery of riboflavin was over 96%.The detection limits of riboflavin was 5ng·ml -1 ,and the calibration curve was linear in the range of 5ng·ml -1 ～3μg·ml -1 .The regression equation was △F′ =0.116c+0.232( r =0.9999).CONCLUSION:The concentration time curves of riboflavin in salive was similar to these in plasma.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
1999年第2期122-123,共2页
Chinese Pharmaceutical Journal
