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盐酸帕洛诺司琼、格拉司琼、昂丹司琼预防化疗呕吐的比较 被引量:20

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摘要 目的:观察三种止吐药预防化疗引起呕吐的临床疗效和不良反应。方法:采用DDP化疗方案治疗的肿瘤患者60例随机分为3组,分别给予国产帕洛诺司琼、格拉司琼、昂丹司琼,观察3种药物预防呕吐的效果。结果:急性期防治呕吐的有效率帕洛诺司琼组为75%,格拉司琼组为65%,昂丹司琼组为55%;延迟期分别为70%,55%和50%,3种止吐药毒副反应均为便秘、腹泻及头痛,但程度较轻。结论:帕洛诺司琼、格拉司琼、昂丹司琼是DDP化疗方案患者的有效止吐药,帕洛诺司琼疗效最强,3种药物不良反应轻,病人可耐受。
作者 黄雄
出处 《贵阳医学院学报》 CAS 2010年第3期296-297,299,共3页 Journal of Guiyang Medical College
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  • 1Piraccini G,Stolz R,Tei M,et al.Pharmacokinetic features of a novel 5-HT3-receptor antagonist:palonosetron (RS 25259-197)[J].Proc Am Soc Clin Oncol 2001(20):400a (Abstr 1595).
  • 2Macciocchi A,Gallagher S.A phase II dose-ranging study to assess single intravenous doses of palonosetron for the prevention of highly emetogenic chemotherapy-induced nausea and vomiting[J].Proc Am Soc Clin Oncol,2002(21):471a (Abstr 1480).
  • 3Gmlh R,Lichinitser M,Vegt SV,et al.Palonosetron improves prevention o f chemotherapy induced nausea and vomiting following moderately emetoge-nic chemotherapy:results of a double-blind randomized phaseⅢ trial comparing single doses of palono-setron with ondansetron[J].Ann of Oncol,2003(10):1570-l577.
  • 4Johnston D,Latreille J,Laberge F,et al.Preventing nausea and vomiting during days 2-7 following high dose cisplatin chemotherapy (HDCP).A study by the National Cancer Institute of Canada Clinical Trials Group (NCICCTG)[J].Proc Am Soc Clin Oncol,1995(14):529 (Abstr 1745).
  • 5Kaizer L,Warr D,Hoskins P,et al.Effet of schedule and maintenance on the antiemetic efficacy of ondansetron combined with dexamethasone in acute and delayed nausea and emesis in patients receiving moderately emetogenic chemotherapy:a phase III trial by the National Cancer Institute of Canada Clinical Trials Group[J].J Clin Oncol 1994(12):1050-1057.
  • 6Aapro MS,Thuerlimann B,Sessa C,et al.A randomized,double-blind trial to compare the clinical efficacy of granisetron with metoclopramide,both combined with dexamethasone in the prophylaxis of chemotherapy-induced delayed emesis[J].Ann Oncol,2003(14):291-297.
  • 7Eisenberg P,Figueroa -Vadillo J,Zamora R,et a1.Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonose tron,a pharmacologically novel 5 -HT 3 receptor antagonist:results of a phase III,single-dose trial versus dolasetren[J].Cancer,2003(11):2473-2482.

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