摘要
目的揭示Ⅳ型胶原酶与肝细胞癌（ＨＣＣ）侵袭转移性的关系。方法通过明胶酶谱法对ＨＣＣ癌、癌旁肝组织及血浆中Ⅳ型胶原酶含量进行测定，并与反映ＨＣＣ侵袭转移性的病理指标进行统计学分析。结果ＨＣＣ及其癌旁肝组织均有Ⅳ型胶原酶表达；ＨＣＣ组织中Ⅳ型胶原酶含量升高及基质金属蛋白酶２（ＭＭＰ２）活性形式的出现与ＨＣＣ侵袭转移性有关；血浆中Ⅳ型胶原酶含量的升高与ＨＣＣ侵袭转移有关。结论Ⅳ型胶原酶与ＨＣＣ侵袭转移性有关。
Objective To achieve the insights into the relationship between type Ⅳ collagenase and the invasion and metastasis of hepatocellular carcinoma (HCC). Methods Zymography was used to study the type Ⅳ collagenase content in the HCC, and statistics were made to analyze the association between the content of type Ⅳ collagenase and the invasive and metastatic indexes of HCC.Results Type Ⅳ collagenase existed in all HCC tumor, surrounding liver parenchyma and the plasma; the increase of type Ⅳ collagenase and the presence of active MMP 2 were related to the invasiveness and metastasis of HCC; the increase of plasma type Ⅳ collagenase was also related to the invasion and metastasis of HCC.Conclusion Type Ⅳ collagenase is related to invasion and metastasis of HCC.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1999年第1期13-15,共3页
Chinese Journal of Digestion
基金
上海市医学领先学科基金
美国中华医学基金会基金
关键词
金属蛋白酶
细胞外基质
肝细胞癌
肿瘤侵袭
Metalloproteinase Extracellular matrix Hepatocellular carcinoma Neoplasm invasion Metastasis
