摘要
为研究螺旋藻对实验性矽肺大鼠体内抗氧化水平的作用，实验设空白对照组、染尘对照组和染尘螺旋藻实验组，用非暴露式气管注入法复制大鼠矽肺模型，饲养１２周。结果表明：螺旋藻能显著提高染尘大鼠超氧化物歧化酶和谷胱甘肽过氧化物酶抗氧化酶的活性，降低肺组织中丙二醛的含量和支气管肺泡灌洗液中乳酸脱氢酶、酸性磷酸酶的含量。结果提示：（１）螺旋藻具有提高实验性矽肺大鼠体内抗氧化水平的作用；（２）螺旋藻在一定程度上能延缓或抑制矽肺病变的发展；（３）螺旋藻提高机体抗氧化水平的作用机理可能与其含有的微量元素Ｓｅ和β胡萝卜素等营养成分有关。
In order to explore the effect of spirulina on antioxidation of silicosis,the silicosis model was prepared by non exposure bronchus injection.Mice were divided randomly into three groups:control group,silica group and spirulina+silica group.The results showed that spirulina could significantly eleraked the activity of SOD and GSH Px of the silica exposed mice meantime reduced the content of MDA in lungs and ACP、LDH in BALF.The result suggests that:1.Spirulina possesses the ability of enhancing the antioxidation level of silicosis mouse in vivo.2.Spirulina can partly restrain the development of silicosis.3.The mechainsm of the effect probably related to the nutritional compositions spirulina contains such as trace element Se and Beta carotene.
出处
《中国工业医学杂志》
CAS
1999年第1期8-9,共2页
Chinese Journal of Industrial Medicine
