摘要
胆管癌是一种破坏力极强的恶性肿瘤,具有低诊断率和高病死率的特点,手术是其唯一的根治方法,然而患者就诊往往在进展期,所以目前胆管癌的根治率很低,且手术复发率很高.胆管癌沿周围神经浸润是胆管癌发生发展过程中特别是在早期具有的非常重要的特性,且与术后复发率和预后密切相关.因此,如果了解胆管癌周围神经浸润的相关机制,早期对其进行干预,必将大大提高患者的手术切除率及预后.本文重点就目前胆管癌神经浸润研究最热门的几个可能的分子及其可能的相关机制进行综述.
Cholangiocarcinoma is a type of malignant tumor with high destruction.Due to its low diagnostic rate and high fatality rate,the operation is the unique therapeutic methods for the radical cure.However,the diagnosis and treatment for the disease were always in the phase of progression,so currently,the radical therapeutic rate is quite low,while the recurrence rate of the operation is extremely high.If the correlated mechanism of perineural invasion of cholangiocarcinoma could be understood,then interrupted its perineural invasion in the early period,that could greatly enhance the prognosis of cholangiocarcinoma patients.This article systematically reviews the progress of cholangiocarcinoma neural invasion related molecules and possible mechanism.
出处
《国际外科学杂志》
2010年第7期479-483,共5页
International Journal of Surgery
关键词
胆管癌
神经浸润
神经生长因子
神经黏附分子
基质金属蛋白酶
神经递质
转化生长因子
Cholangiocarcinoma
Perineural invasion
Nerve growth factor
Neural cell adhesion molecule
Matrix metalloproteinase
Neurotransmitter
Transforming growth factor
