摘要
用２，４－二氯－６－硝基酚铵（ＤＣＮＰＡ）进行小鼠肺肿瘤诱发试验。分别作ＤＣＮＰＡ１次腹腔注射染毒，ＤＣＮＰＡ１次染毒＋ＢＨＴ促进，和ＤＣＮＰＡ１次染毒＋ＢＨＴ促进＋ＤＣＮＰＡ演进３个试验。结果提示ＤＣＮＰＡ为完全致癌物，因为ＤＣＮＰＡ不需ＢＨＴ促进即能诱发肺腺瘤，试验结果也提示ＤＣＮＰＡ有一定的演进作用。
Carcinogenicity of 2,4 dichloro 6 nitrophenolate amnonium (DCNPA) was deteded by mouse lung tumor short term induction assay.It was tested by 3 differant models,i.e.DCNPA single injection(i.p.) exposure,DCNPA single injection+BHT promotion,and DCNPA single injection+BHJ promotion+DCNPA progression.The results suggested that DCNPA is a complete carcinogen,as lung adenomas could be inducted without BHT promotion.The results also demonstrated that DCNPA appeared to play a role in the progression stage of lung carcinogenesis. \ \
出处
《卫生毒理学杂志》
CAS
CSCD
1999年第1期23-25,共3页
Journal of Health Toxicology
基金
国家自然科学基金
关键词
硝基酚铵
肺肿瘤
完全致癌物
肿瘤诱发
dichloro 6 nitrophenolate ammonium
Mouse lung tumor induction
Complete carcinogen
Progressor
