摘要
目的:探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清铁蛋白(serum ferritin,SF)检测的临床意义。方法:对49例T2DM患者以及30例健康体检者分别测定SF,按SF高低将T2DM患者分为正常SF组和高SF组,检测并比较两组患者空腹血糖(fastingplasma glucose,FPG)、餐后2h血糖(2h glucose,2hPG)、糖化血红蛋白(glycosylated hemoglobin,HbA1C)、空腹胰岛素(fasting insulin,FINS)、胰岛素抵抗指数(insulin resistance index,HOMA-IR)、尿白蛋白(urinary albumin,UAlb)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)。结果:糖尿病(DM)组与对照组相比,SF水平显著升高,高SF DM患者具有较高的FPG、2hPG、HbAIC、UAlb、HOMA-IR和FINS,差异具有显著性(P<0.01),两组TC和TG无显著区别。结论:T2DM患者体内铁贮备增多,对判断DM病情及早期肾损害有重要的临床价值。
Objective：To explore the clinical significance of serum ferritin levels detection in the patients with type 2 diabetes mellitus.Methods：Serum ferritin was measured in 49 patients with type 2 diabetes and 30 healthy individuals.According to serum ferritinlevel,the patients with type 2 diabetes were divided into normal ferritin group and high serum ferritin group.Fasting blood glucose（FPG）,2h plasma glucose（2hPG）,glycosylated hemoglobin（HbA1C）,fasting insulin（FINS）,insulin resistance index（HOMA-IR）,urinary albumin（UAlb）,total cholesterol（TC）,triglyceride（TG） of two groups were measured and compared.Results：Serum ferritin level was sig-nificantly elevated in the diabetic group compared with the control group.Higher FPG,2hPG,HbAIC,UAlb,HOMA-IR and FINS were ob-served in the patients with diabetes in high serum ferritin group than in low serum ferritin group.there was no significant difference in TCand TG detection.Conclusion：Iron reserves are increased in the patients with type 2 diabetes.Serum iron detection has important clini-cal value in the prognosis of disease condition and early renal damage in diabetes patients.
出处
《现代医药卫生》
2010年第14期2087-2088,共2页
Journal of Modern Medicine & Health
