摘要
目的探讨血清胱抑素C在2型糖尿病患者早期肾脏损害诊断中的临床价值。方法采用胶乳增强的散射免疫比浊法测定血清胱抑素C,尿微量白蛋白(MK),β2微球蛋白(β2-MG),尿微球蛋白(a1-MG),转铁蛋白(TRF),并与健康对照组进行比较。结果 2型糖尿病患者血清胱抑素C,MK、β2-MG、a1-MG、TRF尿浓度比健康对照组显著增高(P<0.01)。结论肾损害是2型糖尿病的严重并发症之一,血清Cystatin是糖尿病早期肾脏损害的灵敏指标,联合MK、β2-MG、a1-MG、TRF检测,对于2型糖尿病肾脏损害早期的诊断具有重要意义。
Objective To discuss the diagnostic significance of serum cystatin for detection of early renal impairment in patientswith type Ⅱ diabetes.Methods Serum cystatin was examined by adoption of latex enhanced turbidimetry,and the figures of type II diabetic patients were compared with those of healthy persons.Results In patients with type Ⅱ diabetes,the concentrations of serum cystatin and urinary MK,β2-MG,a1-MG and TRF were significantly higher than those of healthy persons,and their difference was statistically significant（P 0.01）.Con-clusion Renal impairment is one of the serious complications in patients with type Ⅱ diabetes.Serum cystatin is a sensitive index for detection of early renal impairment in diabetic patients.Combined examination of serum cystatin and urinary MK,β2-MG,a1-MG and TRF is very impor-tant in early diagnosis of renal impairment in patients with type II diabetes mellitus.
出处
《临床和实验医学杂志》
2010年第22期1689-1690,共2页
Journal of Clinical and Experimental Medicine
