摘要
本实验室及国外实验室已报道Ｂ组维生素Ｂ１，Ｂ６，Ｂ１２的镇痛作用，但维生素Ｂ２对痛阈的影响，尚未见报道。实验应用辐射热甩尾法测痛，刺激坐骨神经Ｃ类纤维诱发体感皮层电反应（平均诱发电位），以［３Ｈ］标记放免测定血中前列腺素Ｅ２，探讨了维生素Ｂ２对大鼠痛阈的影响及其机制。结果证明，腹腔注射７５和１５０ｍｇ／ｋｇ维生素Ｂ２可降低大鼠痛阈；而且可被由腹腔注射的醋氨酚所对抗。放免测定血中前列腺素证明注射维生素Ｂ２后，血中前列腺素含量明显升高。因而认为，维生素Ｂ２降低大鼠痛阈的作用，可能与外周前列腺素含量升高有关。
The analgesic effect of vitamine B 1 ,B 6, and B 12 has been shown in several laboratories. But there is no report concerning the analgesic effect of vitamine B 2 yet .In the present study radiant heat induced tail flick latency test,the recording of somatosensory evoked potential of C fiber by stimulating sciatic nerve and radioimmuneoassay of blood plasm prostagladin E 2 (PGE 2) were done to observe the effect of vitamine B 2 on the pain threshold.The vitamine B 2(75 and 150mgkg,i.p.) decreased the pain threshold in rats .The hyperalgesic effect of vitamine B 2 was blocked by paracetamol(ip.) and the plasm content of PGE 2 increased significantly after injection of vitamine B 2(i.p.).The results suggested that there is a possible relationship between the decreasing pain threshold by vitamine B 2 and the increasing of the PGE 2 in perpheral blood.
出处
《中国疼痛医学杂志》
CAS
CSCD
1999年第1期41-44,共4页
Chinese Journal of Pain Medicine
关键词
维生素B2
痛阈
前列腺素
RI
Vitamine B 2
Pain threshold
Radioimmunoassay
Prostagladin E 2
