摘要
报道１８个Ｎ甲基Ｎ（ｍ，ｐ取代苄基）α取代萘苄胺类化合物的合成及抗真菌活性．抑菌测试结果表明：目标化合物对常见８种致病真菌均有不同程度的抑制活性，对浅表真菌活性好于深部真菌，与萘替芬（ｎａｆｔｉｆｉｎｅ）相当，优于克霉唑（ｃｌｏｔｒｉｍａｚｏｌｅ），低于布替萘芬（ｂｕｔｅｎａｆｉｎｅ）．化合物（７），（８），（１３），（１４）等对Ｓ．ｓｃｈｅｎｃｋｉ活性是萘替芬及克霉唑的３０～６０倍，化合物（２），（７），（８），（１４）对Ｅ．ｆｌｏｃｏｓｕｍ的活性是萘替芬的２～４倍。
Eighteen N methyl N (m,p substituted benzyl) α substituted naphthalenemethan amines were synthesized and seventeen of them are reported for the first time.Results of preliminary biological tests suggested that all the title compounds were active against the eight tested fungi to different degrees.Compounds (7),(8),(13) and (14) were 30～60 times more active than naftifine and clotrimazole against S.schenckii. Compounds (2),(7),(8) and (14) were 2～4 times more active than naftifine,30～60 times more active than clotrimazole against E.floccosum.
出处
《中国药物化学杂志》
CAS
CSCD
1999年第1期7-12,共6页
Chinese Journal of Medicinal Chemistry
基金
总后"九五"重点基金
关键词
取代萘苄胺类
合成
抗真菌活性
substituted naphthalenemethanamines
synthesis
antifungal activity
