摘要
目的评价立体定向高分次剂量同步紫杉醇联合卡铂方案（TC方案）化疗治疗中、晚期非小细胞肺癌的疗效及不良反应。方法 28例ⅡB期、56例Ⅲ期非小细胞肺癌患者入组,应用全身伽玛刀立体定向高分次剂量放疗,同期TC方案化疗4周期,每3周重复。结果有效率：其中ⅡB期85.7%,Ⅲ期76.8%;远期生存：ⅡB期1、2、3年生存率分别为82.1%、57.1%、42.9%,中位生存期32.6个月,中位无进展时间15.5个月;Ⅲ期1、2、3年生存率分别为73.2%、42.9%、21.4%,中位生存期21.5个月,中位无进展生存时间11.2个月;Ⅰ~Ⅱ级放射性食管炎发生率32.1%,放射性肺炎发生率仅为17.9%,Ⅲ~Ⅳ级放射性食管炎发生率5.4%,未见Ⅲ~Ⅳ级放射性肺炎发生。结论立体定向高分次剂量同步TC方案化疗治疗中、晚期非小细胞肺癌是一种短疗程、安全、有效的综合治疗模式,值得临床推广应用。
Objective To evaluate the therapeutic effects and side reaction of hypofractionated high-dose radiotherapy concurrently combined with taxel and carboplain（TC） regimen for stageⅡB and stage Ⅲ non-small cell lung cancer（NSCLC）.Methods 84 patients entered the protocol,in which 28 patients were with stage ⅡB,56 with stage Ⅲ.Hypofractionated high-dose radiotherapy was applied,and TC regimen chemotherapy was given for 4 cycles,repeated for 3 weeks.Results The response rate for stage ⅡB was 85.7%,stage Ⅲ 76.8%.Median survival time for stage ⅡB was 32.6 months.Median progression-free survival time was 15.5 months.1,2,and 3 year survival rate was 82.1%,57.1% and 42.9%,respectively.Median survival time for stage Ⅲ was 21.5 months.Median progression-free survival was 11.2 month.1,2,and 3-year survival rate was 73.2%,42.9%,21.4%,respectively.For radioactive esophagitis,grade Ⅰ-Ⅱ was 32.1%,Grade Ⅲ-Ⅳ was 5.4%.GradeⅠ/Ⅱ of radioactive pneumonia was 17.9%.No Grade Ⅲ-Ⅳ of radioactive pneumonia happened.Conclusion Hypofractionated high-dose radiotherapy combined with TC regimen chemotherapy concurrently is active and well tolerated for patients with stage ⅡB/Ⅲ NSCLC.
出处
《临床荟萃》
CAS
2010年第14期1218-1220,1223,共4页
Clinical Focus
基金
甘肃省科技厅科学事业费资助项目(QS061-C33-34)
关键词
癌
非小细胞肺
放射外科手术
化疗方案
预后
carcinoma
non-small cell lung
radiosurgery
antineoplastic combined chemotherapy prorocols
prognosis
