摘要
目的和方法：自发性高血压大鼠（ＳＨＲ）及相应的正常血压对照大鼠（ＷｉｓｔａｒＫｙｏｔｏ大鼠，ＷＫＹ）静注［３Ｈ］苯丙氨酸后的药物动力学及组织摄取。结果：苯丙氨酸在大鼠的药物动力学符合二室开放模型。与ＷＫＹ相比，ＳＨＲ中苯丙氨酸消除半衰期延长，清除率缩小，药时曲线下面积增加，中央室表观分布容积增加，心脏对苯丙氨酸摄取增加。
AIM and METHODS: Pharmacokinetics and tisssure uptake of phenylalanine in spontaneous hypertensive rat (SHR) and the control rat-Wistar Kyoto rat (WKY) were studied. At different times after i. v. administration of phenylalanine, the radioactive counts in blood and tissures of SHR or WKY were measured with liquid scintillation counter. RESULTS: Pharmacokinetic process of phenylalanine in rats conformed to the open two compartmental model. In SHR T 1/2β was 300±150 min, clearance was (0.56±0.22) mg·min 1 , apparent volume of distribution was (27±13) g and area under concentration-time curve was (8300±3600) counts·min -1 ·mg -1 . The corresponding values in WKY were 110±50,1.40±0.60,13±3 and 4200±2000, respectively. The differences of these values between SHR and WKY were statisically significant ( P <0.01). In SHR the uptake of phenylalanine by heart was (72±29)counts·min -1 ·mg 1 at 2 h after i v administration, which was higher than that in WKY (33±12)counts·min -1 ·mg 1 , P <0.01. CONCLUSION: Hypertension probably belongs to the category related to inherited amino acid metabolic aberration.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第1期21-23,共3页
Chinese Journal of Pathophysiology
基金
国家自然科学基金
关键词
苯丙氨酸
高血压
大鼠
药代动力学
Phenylalanine
Hypertension
Rats
Pharmacokinetics
