摘要
采用可及性和可塑性方案，结合抗原性方案、二级结构方案及综合位点预测方案对人Ｆａｓ抗原的Ｂ细胞表位进行预测，结果显示：人Ｆａｓ抗原Ｂ细胞表位可能位于Ｎ－末端残基５１－７８，１０２－１１０，１４５－１５７等区域内或附近。由于残基１０２、１２０位有２个潜在的Ｎ－糖基化位点（Ａｓｎ－Ｘ－Ｓｅｒ／Ｔｈｒ），对表位的形成有一定影响，人Ｆａｓ抗原的Ｂ细胞表位可能位于５１－７８，１００－１５７区域内。
B cell epitopes of H Fas antigen were predicted by using accessibility and flexibility schemes, associated with antigenicity, secondary structure and multiple site prediction. The results demonstrated that the B cell epitopes of H Fas were probably at or adjacent to its N terminal No. 51 78, 102 110, 145 157. Thinking the B cell epitopes can be affected by two potential site of N glycosy1 in N terminal No. 102,120(Asn X Ser/Thr), the B cell epitopes of H Fas antigen possibly localized in its N terminal No. 51 78, 100 157.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1999年第1期14-16,23,共4页
Immunological Journal
基金
全军"九五"医药卫生科研重点项目基金
