摘要
目的：探讨人群对乙肝疫苗免疫应答与ＨＬＡ遗传多态性的相关性。方法：对５２名湖北汉族健康自愿者进行ＨＢＶ血源疫苗标准全程接种，共３次（第０、１、６月），末次接种后８ｗ用酶免疫法（ＥＩＡ）检测血清抗ＨＢｓ抗体水平：Ｓ／Ｎ≥２１为应答者；Ｓ／Ｎ＜２１为无应答者。同时对受试者进行ＨＬＡＩ类抗原多态性检测。结果：应答者４２人（８１０％），无应答者１０人（１９０％）；无应答者与ＨＬＡＢ３９具有显著相关性，ＲＲ＝１７５，χ２＝５２２，Ｐ＜００５，而与ＨＬＡＢ６２呈负相关，χ２＝６４１，Ｐ＜００５。结论：在湖北汉族人群中，ＨＬＡＢ３９表型阳性个体对乙肝疫苗免疫应答水平明显低于其他个体，而ＨＬＡＢ６２表型阳性个体明显高于其他个体。
Objective:To study association between the feature of the immune response to hepatitis B vaccine and HLA genetic polymorphism on human.Methods:52 healthy volunteers of the Han nationality from Hubei province were subjected to a standard course of immunization with HBV plasma vaccine at month 0,1 and 6 successively. 8 weeks after the last immunization,serum level of anti HBs antibody were assayed with EIA.Individuals with S/N≥2 1 are responders,and S/N<2 1 are nonresponders. Results:42(81 0%) of the 52 subjects were responders,10(19 0%) individuals were nonresponders.Unresponsiveness of the 10 individuals to hepatitis B vaccine were found to be positively associated with HLA B39(RR=17.5,χ 2=5.22,P<0.05) and negatively associated with HLA B62(χ 2=6.41,P<0.05),as demonstrated by HLA I antigen polymorphism analysis.Conclusion:The level of immune response to hepatitis B vaccine of individuals bearing HLA B39 antigen was significantly lower than others,individuals bearing HLA B62 antigen was significantly higher than others.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1999年第1期20-22,共3页
Chinese Journal of Immunology
