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B7-H4与移植免疫 被引量：1

B7-H4 and transplantation immunology
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摘要 B7-H4是2003年发现的B7家族成员,在T细胞介导的免疫中起负调节作用,抑制T细胞增殖和细胞因子分泌。尽管其mRNA在淋巴组织和非淋巴组织均有表达,但其蛋白质在正常组织、细胞中不表达或极低表达。本文就B7-H4与移植免疫的相关研究进展作一综述。 B7-H4, a B7 family member, which was found in 2003 plays negatively regulating effect of T-cell mediated immune response via inhibiting T-cell proliferation and cytokines production. Although B7-H4 mRNA expression is seen in lymph and nonlymph tissues, protein is down-expressed or not expressed in normal tissues and cells. This study is to review advances in B7-H4 associated-transplantation immunology.
作者 金成彦 姜睿 赵吉光 孙梅 李金东 张兴义
机构地区 吉林大学白求恩第二医院胸外科 吉林大学中日联谊医院骨科 吉林大学白求恩第二医院心血管内科
出处 《中国实验诊断学》 北大核心 2010年第6期954-958,共5页 Chinese Journal of Laboratory Diagnosis
基金 国家自然科学基金资助(合同号:30870354) 吉林省科技厅资助(合同号:20070720200805120) 吉林省发展与改革委员会资助(合同号:2009Y042J12314) 吉林省卫生厅科研资助(合同号:20089002) 2007年吉林大学科研种子基金资助
关键词 B7-H4 共刺激分子 移植 免疫学 B7-H4 co-stimulating molecule, transplantation, immunology
分类号 R392 [医药卫生—免疫学]
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二级参考文献13

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共引文献15

同被引文献15

  • 1Zou W,Chen L.Inhibitory B7-family molecules in the tumour microenvironment[J].Nat Rev Immunol,2008,8(6):467-477.
  • 2Kryczek I,Wei S,Zou L,et al.Cut ting edge:induction of B7-H4 on APCs through IL-10:novel suppressive mode for regulatory T cells[J].J Immunol,2006,177(1):40-44.
  • 3Suh WK,Wang S,Duncan GS,et al.Generation and characterization of B72H4/B7S1/B7x2 deficient mice[J].Mol Cell Biol,2006,26(17):6403-6411.
  • 4Zang X,Thompson RH.AI-Ahmadie HA,et al.B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome[J].Proc Natl Acad Sei USA,2007,104(49):19458-19463.
  • 5Sun Y,Wang Y,Zhao J,et al.B7-H3 and B7-H4 expression in non-small-cell lung cancer[J].Lung Cancer,2006,53(2):143-151.
  • 6Jiang J,Zhu Y,Wu C,et al.Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer[J].Cancer Immunol Immunother,2010,59(11):1707-1714.
  • 7夏铭,杨廷旭,王伟,苗龙,曾海龙,姚建华.胃癌患者T细胞亚群变化的临床意义[J].临床医学,2009,29(1):105-105. 被引量：17
  • 8王公平,冯笑山,周博.贲门癌组织中CD3^+T细胞的数量与临床病理指标间的关系[J].医学研究杂志,2009,38(5):66-68. 被引量：4
  • 9蒋敬庭,吴昌平,沈月平,朱一蓓,陈陆俊,孙静,胡文蔚,孔炯,吴鸿雅,Lu Binfeng,张学光.共刺激分子B7-H4在胃癌组织中表达及其与预后的关系[J].中华实验外科杂志,2009,26(9):1155-1158. 被引量：29
  • 10黄健,李小宁,赵英伟.人结肠直肠癌组织中B7-H4的表达及其临床意义[J].安徽医药,2009,13(8):910-912. 被引量：3

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中国实验诊断学
2010年 第6期

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