摘要
目的探讨共刺激分子B7-H4在结肠直肠癌组织中的表达及其意义。方法运用免疫组织化学S-P法检测B7-H4分子在60例结肠直肠癌组织中的表达,并对其表达水平与结肠直肠癌临床病理参数之间的关系进行相关性分析。结果B7-H4在结肠直肠癌组织中高表达,阳性率为83.3%;在结肠直肠癌组织中B7-H4的表达与患者性别、年龄、肿瘤组织的类型、分级和分期无关(P>0.05),而与淋巴结是否转移显著相关(P<0.05)。结论B7-H4在结肠直肠癌组织中的高表达,可成为结肠直肠癌新的诊断标志。B7-H4在肿瘤的发生、进展中起到一定作用,封闭B7-H4有可能成为结肠直肠癌免疫治疗的一个新靶点。
Aim To investigate the expression of B7-H4 in human colon and rectal carcinoma and the relationship between their expression and the clinicopathological features.Method Immunohistochemical staining was used to detect the expression of B7-H4 in 60 cases of colon and rectal carcinoma tissues.Results B7-H4 was high expressed in colon and rectal carcinoma.The expression rate of B7-H4 was 83.3%.There was no correlation between the expression level of B7-H4 and sex,age,histological types,grade and state（P〉 0.05 ）, but significant correlations could be demonstrated with lymph node metastasis （ P 〈 0.05 ）. Conclusion B7-H4 is overex- pressed in colon and rectal carcinoma and may be a new marker of diagnosis for colon and rectal carcinoma. B7-H4 plays certain role in oncogenesis and progression of human colon and rectal carcinoma. The blockade of B7-H4 might be a new target of immunotherapy of colon and rectal carcinoma.
出处
《安徽医药》
CAS
2009年第8期910-912,共3页
Anhui Medical and Pharmaceutical Journal
