摘要
目的研究硫酸镁对sTBI患者血清IL1β和TNFα浓度的影响,进一步探讨镁离子保护创伤神经元的机制。方法将入选病例随机分为治疗组和对照组,每组30例。对照组按常规治疗,治疗组加用硫酸镁。正常组20例,为成年健康献血员。按预设时间抽取肘静脉血,采用原子分光光度法和放射免疫法分别测定血清Mg2+与IL1β、TNFα浓度。应用SPSS13.0软件包分析数据。结果 sTBI后血清IL1β和TNFα浓度24h内即明显升高,3d达到高峰,以后逐渐下降;治疗组患者血清IL1β浓度于伤后2、3、7d和TNFα于伤后2、3d明显低于对照组(P<0.01或P<0.05)。结论 sTBI患者伤后早期即出现血清IL1β和TNFα浓度升高;早期应用硫酸镁治疗能明显抑制sTBI患者急性期炎症反应,保护神经功能。
Objective To study the effects of magnesium sulfate on the serum concentration of interleukin 1β （IL1β） and tumor necrosis factor α （TNFα） in patients with severe traumatic brain injury （sTBI） and investigate the mechanism of magnesium ion （Mg2＋）＇s protective effect on traumatic neurons. Methods The recruited patients were randomly assigned to experimental group and control group,with 30 cases in each group. Patients in control group were treated by the routine method. Apart from the standardized treatment,patients in experimental group were treated with magnesium sulfate additionally. Normal group consisted of 20 healthy adult donors of blood. We collected elbow venous blood samples at preset time from the subjects,serum levels of Mg2＋,IL1β and TNFα were measured by atomic spectrometry and radioimmunoassay,respectively. Then the data were analyzed by SPSS13.0 software package. Results The serum levels of IL1β and TNFα increased significantly within 24 hours and reached the peak on day 3,then gradually declined after sTBI. The serum concentration of IL1β on day 2,3,7 and that of TNFα on day 2,3 after sTBI was lower in experimental group than in control group （P0.01 or P0.05）.Conclusion The serum concentration of IL1β and TNFα in patients increases in the early period of sTBI. Early application of magnesium sulfate can obviously inhibit the acute inflammatory response in acute phase of sTBI and protect neuronal function.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第4期497-500,共4页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
陕西省卫生厅科研基金资助项目(No .08 H30)~~
