摘要
目的为外伤性癫痫的早期预防和治疗提供依据。方法回顾性分析356例颅脑损伤病人的临床资料,重点分析外伤性癫痫与颅脑损伤类型,患者年龄、性别以及颅脑损伤严重程度和损伤部位的关系。结果 16岁以下儿童和成人外伤性癫痫发生率分别为16.67%(9/54)和6.62%(20/302),两者相较相差显著(P<0.01)。开放性颅脑损伤与闭合性颅脑损伤患者癫痫的发生率分别为29.73%(11/37)和5.64%(18/319),两者相较相差显著(P<0.01);脑挫裂伤合并脑内血肿、弥漫性轴索损伤及凹陷性颅骨骨折患者的癫痫发生率分别为16.94%(21/124)、20.51%(8/39)和10.53%(4/38),明显高于CT检查未见颅内明显异常的98例颅脑损伤患者的癫痫发生率1.02%(P<0.05)。结论开放性颅脑损伤、脑挫裂伤并脑内血肿、弥漫性轴索损伤、凹陷性颅骨骨折及年龄16岁以下可能是外伤性癫痫的危险因素。
Objective To provide the basis for clinical prevent and treatment of post-traumatic epilepsy（PTE）.Method The clinical data of 356 patients with traumatic brain injury,including injury type,patients＇ age and sex,severity of head injury,injured regions and their relationship with the PTE,were analysed retrospective.Results The incidence of PTE（16.67%,9/54） was significantly higher in the brain injury children under 16 years of age than that（6.62%,20/302） in the adults with brain injury（P0.01）.The incidence （29.73%,11/37） of PTE in the patients with open brain injury was significantly higher than that（5.64%,18/359） in the patients with close brain injury（P0.01）.The incidences of PTE in the patients with cerebral contusion and intracerebral hematomas or diffuse axonal injury or depressed fracture,which were 16.94%（21/24）,20.51%（8/39） and 10.53%（4/38） respectively,were significantly higher than that （1.02%,1/98） in the patients without significantly abnormal intracranial change on CT images after the brain injury（P0.05）.Conclusion The risk factors related to PTE include open brain injury,cerebral contusion companied with intracerebral hematoma,diffuse axonal injury,depressed fracture and children under 16 years of age.
出处
《中国临床神经外科杂志》
2010年第6期344-346,共3页
Chinese Journal of Clinical Neurosurgery
关键词
颅脑外伤
继发性癫痫
险因素
Craniocerebral injury
Secondary epilepsy
Risk factor
