摘要
心力衰竭是严重威胁人类生命的疾病,当传统的药物治疗有一定局限性,不能达到满意疗效,心脏移植又面临供体缺乏,术后排斥反应等困难的时候,心室辅助装置(ventricular assist device,VAD)的作用就显得异常重要。VAD是应用机械或生物机械手段、部分或全部替代心脏的泵功能。自上个世纪60年代在临床应用以来,经过多年研究和临床应用,VAD的应用已从心血管手术后复苏、心脏移植过渡或替代,拓展至心肌功能的恢复乃至心力衰竭的永久性治疗。未来随着VAD发展的小型化、高功效、低噪音、低耗能、并发症少、无线能量传输和便于植入等特点,终将成为治疗终末期心力衰竭的主要手段之一。现对VAD的发展历史、临床应用、目前存在的问题以及未来发展趋势等进行综述。
Heart failure is a great threat to human health.When conventional drug treatments have limitations and transplantation confronts problems of immunoreaction and lacking donors,the ventricular assist device （VAD） has irreplaceable importance.The VAD substitutes total or part of the heart as a blood pump by using mechanical or biologic-mechanical method.Since its clinical application from the 1960s,after a long time of research and application practice,it has been applied to post-operative cardiovascular recovery,heart transplantation and replacement,myocardiac recovery and permanent therapy for heart failure.In the future,VAD will develop toward such characteristics as miniaturization,high efficiency,low noise,low power consumption,fewer complications,wireless energy transmission and easy implantation,which will surely make it one of the major treatments for heart failure.This article will have a comprehensive review on the development of VAD,its clinical application,current problems and future development direction of VAD.
出处
《中国胸心血管外科临床杂志》
CAS
2010年第3期230-234,共5页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
基金
科技部"863"计划(2007AA02Z439)
上海医学领军人才培养计划(LJ06051)~~
关键词
心室辅助
心室辅助装置
临床应用
Ventricular assist
Ventricular assist device
Clinical application
