期刊文献+

维生素E上调高脂饲料型肥胖大鼠白色脂肪组织过氧化物酶体增殖剂激活受体γ mRNA表达 被引量:1

Vitamin E Up-regulates White Adipose Tissue Perooxisomal Proliferator Activated Receptor γ mRNA Expression in Rat of Diet-induced Obesity
原文传递
导出
摘要 过氧化物酶体增殖剂激活受体γ(PPARγ)是唯一在脂肪组织中高水平表达的转录因子,也是前脂肪细胞分化过程中重要的调节因子。PPARγ可促进脂质的氧化代谢,降低血脂浓度,并改善2型糖尿病患者的胰岛素敏感性。
出处 《营养学报》 CAS CSCD 北大核心 2010年第3期301-303,共3页 Acta Nutrimenta Sinica
基金 上海市科委重点建设项目(No.04dz14008) 上海交通大学医学院2008年院基金
关键词 肥胖 氧化应激 PPARΓ 维生素E obesity oxidative stress PPARγ vitamin E
  • 相关文献

参考文献10

  • 1沈秀华,蔡威,汤庆娅,冯一,吴江.营养性肥胖大鼠氧应激水平的改变[J].卫生研究,2007,36(4):440-442. 被引量:8
  • 2Almeida M, Ambrogini E,Han L, et al.Oxidative stress stimulates the synthesis of PPAR gamma 2, and ligand-activated PPAR gamma 2 sequesters beta-catenin leading to suppression ofTCF-mediatedtranscription: anexpla nation for the age related decrease inosteoblastogenesis and increase in adipogenesis[J]. J Bone Miner Res. 2009, 23: S29-S29.
  • 3DobrianAD, Schriver SD, KhraibiAA, et al. Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity[J]. Hypertension, 2004,43: 48- 56.
  • 4KimHa-il, Ji YoungCha, So-YounKim, etal. Peroxisomal proliferator - activated receptor-upregulates glucokinase gene expression in cells[J]. diabetes, 2002,51: 676-685.
  • 5Tontonoz P, HuE, Graves RA, etal. mPPARgamma2: tissue specific regulator of an adipocyte enhancer[J]. Genos Dev, 1994, 8: 1224- 1234.
  • 6Barroso I, Gurnell M, Crowley VE, et al. Dominant negative mutations in human PPAR gamma associated with severe insulin resistance, tension [J], Nature, 1999 diabetes mellitus and hyper 402: 860- 861.
  • 7Coll the PPAR ino M, Aragno M, Ma oxidative stress -gamma agonists in stro and the cola R, et a7. Modulation of inflammatory response by hippocampus of rats exposed to cerebral ischemia/reperfusion[J]. Eur J Pharmacol 2006, 530: 70-80.
  • 8HwangJ, KleinhenzDJ, HeidiL, et al. ThePPARY ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice[J]. Vasc Pharmacol.2007.46: 456-462.
  • 9Clara D, Maria M, Vania P, et al. Increased expression of transglutaminase-1 and PPARY after vitamin E trea tment in human keratinocytes[J]. Arch Biochem Biophys, 2006.447: 97- 106.
  • 10蔡东升.肥胖、糖尿病研究的热点——脂肪细胞分化[J].辽宁实用糖尿病杂志,2000,2(2):2-5. 被引量:7

二级参考文献19

  • 1孙文广,孙长颢.高能饲料诱导大鼠肥胖及对其脂质代谢的影响[J].中国公共卫生,2004,20(5):514-515. 被引量:6
  • 2葛可佑.中国营养科学全书[M].北京:人民卫生出版社,2004.1049-1056.
  • 3Valve R, Sivenius K, Miettinen R, et al. Two polymorphisms in the peroxisome proliferator - activated receptor - gamma gene are associated with severe overweight among obese women. J Clin Endocrinol Metab 1999,84(10):3708.
  • 4Freake HC. A genetic mutation in PPAR gamma is associated with enhanced fat cell differentiation: implicationsfor human obesity. Nutr Rev 1999, 57(5 Pt 1) :154.
  • 5Kubota N, Terauchi Y, Miki H, et al. PPAR gamma mediates high - fat diet - induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999, 4 (4) :597.
  • 6Zhou YT, Wang ZW, Higa M, et al. Reversing adipocyte differentiation: implications for treaatment of obesity. Proc Natl Acad Sci USA 1999,96(5) :2391.
  • 7Edvardsson U, Bergstrom M, Alexandersson M, et al.Rosiglitazone(BRL 49653 ), a PPARgamma- selective agonist,causes peroxisome proliferator - like liver effects in obese mice. J Lipid Res 1999,40(7) :1177.
  • 8KEANEY J F,LARSON M G,VASAN R S,et al.Obesity and systemic oxidative stress:clinical correlates of oxidative stress in the framingham study[J].Arterioscler Thromb Vase Biol,2003,23(3):434-439.
  • 9STRAUSS R S.Comparison of serum concentrations of alpha-tocopherol and beta-carotene in a cross-sectional sample of obese and nonobese children (NHANES III)[J].J Pediatr,1999,134(2):160-165.
  • 10DOBRIAN A D,SCHRIVER S D,KHRAIBI A A et al.Pioglitazone prevents hypertention and reduces oxidative stress in diet-induced obesity[J].Hypertension,2004,43:48-56.

共引文献13

同被引文献7

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部