摘要
本文对高效液相整体柱在药物分离分析方面的应用进行了综述.主要介绍了以烷氧基硅烷为主要原料,采用溶胶-凝胶法制备的硅胶整体柱,由于其具有微米级通孔结构和大的比表面积,他们在高效、快速分离小分子物质方面得到广泛地应用.对于聚合物整体柱,主要介绍了包括分子印迹聚合物在内的有机聚合物整体柱在药物分离、生物样品的处理等方面的应用.
In recent years,monolithic supports as stationary phases in high-performance liquid chromatography（HPLC） have become a rapidly burgeoning field.This review summarizes the current achievements and their application in pharmaceutical analysis and separation.One kind is the silica monoliths prepared from tetraalkoxysilane by a sol-gel method with either micrometer-size through-pores or high specific surface areas and well suited for small molecules in HPLC modes.The other kind is the organic polymer-based monoliths including monolithic molecularly imprinted polymers in treatments of the samples before injected into the chromatograph in biological fluids.The analytical potential of these columns is demonstrated with separations involving various drugs in different chromatographic modes.
出处
《中国科学：化学》
CSCD
北大核心
2010年第6期631-640,共10页
SCIENTIA SINICA Chimica
基金
国家自然科学基金项目(20375010&20675084)
河北省科技攻关项目(06276479D&07276407D)
河北省自然科学基金项目(B2007000146)
河北省教育厅项目(2008416)
河北大学自然科学基金项目(2009-165)资助
关键词
药物分析
分离
整体柱
高效液相色谱
pharmacertical analysis
separation
monolithic column
HPLC
