摘要
我们应用ａｃｔｉｎ（平滑肌型）单克隆抗体对３０例乳腺疾病及肿瘤进行标记，以观察ａｃｔｉｎ的变化，探讨其在早期恶变诊断中的生物学意义。观察可见：乳腺增生病、乳腺纤维腺瘤的肌上皮完整，但肌上皮细胞增生，ａｃｔｉｎ为阳性。乳腺单纯癌、浸润性导管癌、管状腺癌等恶性浸润性肿瘤，ａｃｔｉｎ表达为阴性，说明平滑肌型ａｃｔｉｎ缺如，１例平滑肌肉瘤ａｃｔｉｎ阳性，可与纤维肉瘤、神经纤维肉瘤鉴别。乳腺导管原位癌早期浸润处ａｃｔｉｎ阴性，表明肌上皮细胞消失。乳腺增生病早期恶变处、小叶原位癌早期浸润部分，ａｃｔｉｎ呈阴性反应。因此，ａｃｔｉｎ蛋白的表达，可作为判断乳腺增生病早期恶变、导管原位癌及小叶原位癌早期浸润的重要辅助指标。
We use monoantibody of actin (smooth muscle type)to label 30 breast diseases and tumors,observe the change of actin expression and explore its biological significance in diagnosing early malignant change of diseases. Our observation indicate that the myoepithelium of breast hyperplastic and breast fibroadenoma are contact,but the myoepihtelial cell is hyperplastic,the expression of actin is positive,malignant infiltrative tumor such as breast simple cancer infiltrative ductal cacer tubular adenocarcinoma,the espression of actin protein is negative,show the loss of smooth muscle type actin,one case of leiomyosarcoma,actin is positive,it can help to distinct from fibrosarcoma and neurofibrosarcoma actin at the early invasive situs of breast intraductal cancer is negative,indicate the myoepithelial is disappeared,at the situs of early malignant change of breast hyperplastic diseases and the situs of early infiltrative of lobular carcinoma in situ,the expression of actin is negative.When wu judge the early malignant change of breast hyperplastic disease and early infiltrating of the ductal carcinoma in situ and lobular carcinoma in situ,the expression of actin protein can serve as an important supplementary index.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第1期38-39,共2页
Cancer Research on Prevention and Treatment
