摘要
ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠预免疫２周后，采用由腹腔逐渐过渡至静脉的方法，每日注射阳离子化牛血清白蛋白（ＣＢＳＡ）。结果：静脉注射ＣＢＳＡ２周后，荧光显微镜观察显示ＩｇＧ沿肾小球毛细血管壁呈颗粒状沉积，光镜下可见有新月体形成，电镜下可见大量上皮下电子致密沉积物；４周后，上皮下电子致密沉积物融合成大片状；６周后，较多大鼠出现肾小球硬化。
After two-week preimmunization, Sprague-Dawley rats were daily injected with cationized bovine serum albumin (C-BSA) intraperitoneally. It was found that, after two-week C-BSA intravenous injection, granular deposits of IgG along glomerular capillary walls was shown by fluorescence microscopy, the formation of crescent shown by light microscopy and a large amount of subepithelial electron-dense deposits shown by electron microscopy; after four weeks, subepithelial electron-dense deposits fused into large patches; after six weeks, glomerular sclerosis was found in most rats.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
1999年第1期44-46,共3页
Journal of Beijing University of Traditional Chinese Medicine
