摘要
目的观察奥美拉唑、左氧氟沙星、阿莫西林联合疗法对幽门螺杆菌(Hp)的根除效果及对消化性溃疡(PU)的治疗效果。方法将115例幽门螺杆菌阳性的PU患者随机分为观察组59例和对照组56例。观察组给予奥美拉唑20mg,每天1次;左氧氟沙星500mg,每天1次;阿莫西林1000mg,每天2次。对照组给予奥美拉唑20mg,每天2次;克拉霉素500mg,每天2次;阿莫西林1000mg,每天2次。2组均饭前服用,7d为1个疗程。停药4周后复查胃镜。结果观察组和对照组溃疡治愈率和总有效率分别为86.4%、93.2%和57.1%、62.5%,2组比较差异均有统计学意义(P<0.05);观察组Hp根除率和减少率分别为88.1%、91.5%高于对照组的58.9%和66.1%,差异均有统计学意义(P<0.05)。结论奥美拉唑、左氧氟沙星、阿莫西林联合治疗PU疗程短,疗效高,依从性好,药价合理,值得在基层医院推广应用。
Objective To observe the eradication effect of omeprazole,levofloxacin and amoxicillin triple therapy for helicobacter pylori（Hp）and the therapeutic effect for peptic ulcer（PU）.Methods 115 cases of H.pylori-positive PU patients were randomly divided into observation group（59 cases）and control group（56 cases）.The observation group gaven omeprazole 20mg,once a day;Levofloxacin 500mg,once a day;Amoxicillin 1000mg,2 times a day.While control group gave omeprazole 20mg,2 times a day;Clarithromycin 500mg,2 times a day;Amoxicillin 1000mg,2 times a day.Two groups all ate before meals,7d for a course of treatment.Withdrawal after 4 weeks,reviewed endoscopy.Results Recovery rate and efficient rate of two group respectively were 86.4%,93.2% and 57.1%,62.5%,the difference had a statistical significance（P0.05）;The eradication rate and reduce rate of hewlett-packard in observation graup were higher than that in control group（88.1% vs 58.9%,91.5% vs 66.1%）,the differences were statistical significance（P0.05）.Conclusion Omeprazole,levofloxacin and amoxicillin triple therapy for PU had merits of a short couse,high efficacy,good compliance,reasonable drug prices and cound be widely used in basic-level hospitals.
出处
《临床合理用药杂志》
2010年第12期6-7,共2页
Chinese Journal of Clinical Rational Drug Use
