摘要
目的探讨HBsAg和HBeAg双阳性孕妇其不同的分娩方式对乙型肝炎病毒母婴阻断效果的影响。方法将HBsAg和HBeAg双阳性的母亲所分娩的216例经同样的主被动免疫联合免疫接种后的婴儿,根据不同的分娩方式分为经阴道分娩组102例和剖宫产分娩组114例,采用电化学发光方法检测婴儿7月龄时外周静脉血的乙肝五项,比较两组的母婴阻断效果。结果 102例阴道分娩的婴儿中有6例(5.9%)出现了阻断失败,96例阻断成功(94.1%);而114例剖宫产分娩的婴儿中有5例(4.4%)出现了阻断失败,99例阻断成功(95.6%),两组之间的阻断成功率和失败率无统计学差异(χ2=0.249,P=0.617)。结论 HBsAg和HBeAg双阳性孕妇所分娩的婴儿,经主被动免疫后,阴道分娩与剖宫产手术分娩两种分娩方式对母婴阻断效果无影响。
Objective To explore the effect of different delivery modes on the mother-to-infant transmission of hepatitis B virus for the mothers with hepatitis B surface antigen（HBsAg）seropositive and hepatitis B e antigen（HBeAg）seropositive. Methods A total of 215 HBsAg and HBeAg seropositive mothers and their neonates（n=216）entered the study.According to delivery mode,216 children were divided into vaginal delivery group（n=102） and caesarean section group（n=114）.Serum HBV-markers were detected in 7-month old children and were compared between two groups. Results The positive rates of HBsAg were 5.9% and 4.4% in delivery group and section group,and the positive rates of HBsAb were 94.1% and 95.6%,respectively（χ2=0.249,P=0.617）. Conclusion The delivery modes have no significant difference in blocking the mother-to-child transmission of HBV.
出处
《山西医科大学学报》
CAS
2010年第6期495-497,共3页
Journal of Shanxi Medical University
基金
国家"十一五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项基金资助项目(2008ZX10002-001)
关键词
乙型肝炎病毒
母婴传播
分娩方式
hepatitis B virus
mother-to-infant transmission
delivery mode
