摘要
目的了解国产不同剂量重组乙型肝炎(乙肝)疫苗(酵母)阻断乙肝病毒(HBV)母婴传播的效果。方法用5μg/0.5ml和10μg/0.5ml重组乙肝疫苗(酵母)免疫乙肝病毒表面抗原(HBsAg)、乙肝病毒膜抗原(HBeAg)双阳性母亲的新生儿68例,采用0、1、6个月接种程序,用固相放射免疫(SPRIA)法定量检测乙肝病毒表面抗体(抗-HBs)滴度及HBsAg。结果全程免疫后1个月,10μg剂量组新生婴儿HBsAg阳性率为2.86%,保护率为96.43%;5μg剂量组的HBsAg阳性率为3.45%,保护率为95.69%。10μg、5μg剂量组的抗-HBs阳转率分别为97.14%、82.76%,产生的抗-HBs几何平均浓度分别为237.44毫国际单位/毫升(mIU/ml)、150.06mIU/ml。10μg组的抗体阳转率明显高于5μg组。结论重组乙肝疫苗(酵母)母婴阻断效果良好,10μg组的免疫原性高于5μg组。
Objective To study the efficacy of different doses yeast-derived Hepatitis B vaccine （YDV） to neonates born to HBsAg,HBeAg carrier mother. Methods 68 neonates born to HBsAg,HBeAg carrier mother were vaccined in two groups （5 /lg dose and 10 /lg dose） by 0,1,6 month schedule. Result Vaccined newborns HBsAg positive rate of 10 μg group is 2.86%, the protective rate is 96.43 % ; HBsAg positive rate of 5μg group is 3.45 %, the protective rate is 95.69 % . The anti-HBs seroconversion rate is 97.14%, 82.76%, the mean geometric concentration （GMC）of anti-HBs is 237.44 mIU/mL and 150.06 mIU/mL after 1 month of full vaccination schedule in 10/~g dose group and 5μg dose group respectively. Conclusion The effective anti-HBs conversion rates in 10μg dose group is significantly higher than 5 μg dose group. These results revealed the high efficacy of YDV.
出处
《中国计划免疫》
2006年第4期262-263,共2页
Chinese Journal of Vaccines and Immunization
基金
本课题经费由中国肝炎防治基金会提供
关键词
重组乙型肝炎疫苗(酵母)
免疫效果
Yeast-derived Hepatitis B vaccine
Immounogenicity
Perinatal transmiscion interrruption
Antibody
