摘要
对某橡胶厂工人进行了２３年（１９７３～１９９５）的随访调查，应用多因素分析方法，在控制可能的混杂因素下，分别估计了肺癌、肠癌、胰腺癌、缺血性心脏病和脑血管疾病的危险度。结果显示，亚硝胺的肺癌危险度增高有统计学显著性（ＲＲ＝２７１，９５％ＣＩ＝１３２～５５７）；与肠癌有关的橡胶化合物可能是亚硝胺（ＲＲ＝２４３，９５％ＣＩ＝０６５～９１２）和碳黑（ＲＲ＝２３０，９５％ＣＩ＝０６４～８２６）；与胰腺癌有关的橡胶化合物则可能是溶剂（ＲＲ＝３８４，９５％ＣＩ＝０４６～３２２０）和亚硝胺（ＲＲ＝２７１，９５％ＣＩ＝０６２～１１９１）。由于死亡的病例数较少，肠癌和胰腺癌的相对危险度增高均无统计学显著性，但所揭示的橡胶职业与这两种疾病的关系值得注意和进一步研究。本次研究没有发现橡胶职业暴露与心、脑血管疾病死亡之间的联系。
A cohort of 1549 employees in a rubber factory was followed up from 1973 to
1995.Relative risks for five diseases were separately estimated using multivariate analysis
when effects of non\|occupational risk factors were under control.It was found that the relative
risk(RR=2\^71,95% CI=1\^325\^57)for lung cancer for exposure to nitrosoamines was statistically
and significantly elevated.The occupational exposure to nitrosoamine(RR=2\^43,95%
CI=0\^659\^12)and carbon black(RR=2\^30,95% CI=0\^648\^26)were likely the inducing agents of
the intestinal cancer excess observed among workers in the rubber factory under study.Also,the
occupational exposures to solvent(RR=3\^84,95% CI=0\^4632\^20)and
nitrosoamine(RR=2\^71,95% CI=0\^6211\^91)were likely the inducing agents of the pancreatic
cancer.Due to small size of the samples in this study,the elevated risks related to the
occupational factors for intestinal and pancreatic cancers did not reach statistic significance,but
the results were of etiological importance,which needs to be confirmed in future studies.On the
other hand,the occupational exposures to rubber did not increase the relative risks for ischemic
heart and cerebrovascular diseases.
出处
《工业卫生与职业病》
CAS
CSCD
1999年第1期27-31,共5页
Industrial Health and Occupational Diseases
关键词
橡胶职业暴露
肺癌
肠癌
胰腺癌
心脑血管疾病
Occupational exposure to rubberLung
cancerIntestine and pancreatic cancerIschemic heart and cerebrovascular diseasesRelative
risk
