摘要
目的观察细胞凋亡因子Ｆａｓ抗原与阿尔茨海默病（Ａｌｚｈｅｉｍｅｒｄｉｓｅａｓｅ，ＡＤ）脑神经细胞凋亡的关系。方法采用免疫组织化学的方法，观察Ｆａｓ抗原及β淀粉样蛋白（β－ＡＰ）在６例ＡＤ，５例非痴呆老年人（ＮＤ）大脑皮层、海马、嗅球等部位的表达。结果在ＡＤ脑内Ｆａｓ抗原主要表达于大脑皮质区的神经元胞膜上，而在ＮＤ脑内仅有少量或没有神经细胞呈Ｆａｓ抗原阳性（Ｐ＜０．０１）。同时，我们发现脑皮层Ｆａｓ抗原与β－ＡＰ的分布及阳性度之间呈紧密相关。结论ＡＤ脑内神经细胞的丢失可能与Ｆａｓ抗原介导的细胞凋亡机制相关，并且与β－ＡＰ的沉积有关。
Objective To reveal the correlations between cell apoptosis factor Fas antigen and neuron
apoptosis in the brains of the patients with Alzheimers disease (AD). Methods Using
immunohistochemistry (IHC) technology, we obsered the expression of Fas antigen and β
amyloid protein (β AP) at different regions of cerebral cortex, hippocampus and olfactory ball
in 11 cases autopsy brain, including 6 cases of AD and 5 of non dementia (ND). Results In AD
brains, Fas antigen was mainly expressed in neuron membrane of new cortex. But there was
only less or no expression of Fas antigen in neurons of ND ( P <0.01). In all brains, the
amount and the distribution of Fas antigen expression were closely correlated to those of
expression of β AP.Conclusions The pathogenesis of Fas mediated apoptosis may be
association with neuron decrease and β AP deposited in AD brain.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1999年第1期10-12,共3页
Chinese Journal of Nervous and Mental Diseases
基金
"九五"国家医学科技攻关项目
国家自然科学基金
