摘要
为研究虎耳草[Saxifraga stolonifera(L.)Meeb.]的化学成分,用柱色谱方法进行分离,根据其理化性质和波谱数据鉴定化合物的结构。分离得到了10个化合物,分别鉴定为5-甲氧基异虎耳草素(1)、3,4-二羟基烯丙基苯-4-O-β-D-葡糖苷(2)、(7R,8S)-4,9,9′-三羟基-3-甲氧基-7,8-二氢苯骈呋喃-1′-丙基新木脂素-3′-O-β-D-葡糖苷(3)、槲皮素-3-O-β-D-木糖-(1→2)-β-D-半乳糖苷(4)、山柰酚-3-O-α-L-鼠李糖苷(5)、(3S,5R,6R,7E,9R)-3,5,6,9-四羟基-7-megastigmane(6)、苄基-O-α-L-鼠李糖-(1→6)-β-D-葡糖苷(7)、对羟基苯乙酮(8)、连苯三酚(9)和对羟基苯酚(10)。其中化合物1为新化合物,化合物2～10为首次从该植物中分离得到。
To study the chemical constituents of Saxifraga stolonifera（L.） Meeb.,chromatographic techniques were applied to separate and purify the compounds,and their structures were confirmed on the basis of physicochemical properties and spectral data.Ten compounds were isolated and identified as 5-O-methylnorbergenin（1）,3,4-dihydroxyallylbenzene-4-O-β-D-glucopyranoside（2）,（7R,8S）-4,9,9＇-trihydroxyl-3-methoxyl-7,8-dihydrobenzofuran-1＇-propylneolignan-3＇-O-β-D-glucopyranoside（3）,quercetin-3-O-β-D-xylopyranosyl-（1→2）-β-D-galactopyranoside（4）,kaempferol-3-O-α-L-rhamnopyranoside（5）,（3S,5R,6R,7E,9R）-3,5,6,9-tetrahydroxy-7-megastigmane（6）,benzyl-O-α-L-rhamnopyranosyl-（1→6）-β-D-glucopyranoside（7）,p-hydroxyacetophenone（8）,pyrogallic acid（9） and p-hydroxyphenol（10）.Compound 1 is a new compound.Compounds 2-10 were isolated from this plant for the first time.
出处
《药学学报》
CAS
CSCD
北大核心
2010年第6期742-746,共5页
Acta Pharmaceutica Sinica
基金
supported by the Key Project of Chinese Ministry of Education(2003078)
关键词
虎耳草
化学成分
5-甲氧基异虎耳草素
Saxifraga stolonifera（L.） Meeb.
chemical constituent
5-O-methylnorbergenin
