摘要
研究鸡血藤、赤芍、芡实、白背叶、何首乌、三加皮、肾蕨和青凡木等８种中草药提取物对单纯疱疹病毒１型、水疱性口炎病毒、流感病毒Ａ型、腺病毒３型及艾滋病毒逆转录酶的活性，发现鸡血藤提取物对单纯疱疹病毒１型有强的作用，其５０％细胞病变抑制浓度（ＣＰＩＥ（５０））、５０％细胞致死浓度（ＣＬＥ（５０））和５０％酶活性抑制浓度（ＩＣ（５０））分别为４６．０，６３０，０．２μｇ／ｍｌ，选择毒性指数（ＳＴ）为１３．７．抗病毒的阳性对照物为阿糖胞苷，其ＣＰＩＥ（５０）、ＣＬＥ（５０）和ＳＴ分别为１４．５，２００μｇ／ｍｌ和１３．８。
The extracts of eight kinds of Chinese medicinal herb on antivirus activities were tasted for ability to inhibit the HSV-1/KOS,VSV,Influenza A,Adenovirus 3 and HIV reverse transcriptase.The extracts of Spatholobus suberectus were found to have very strong antivirus activity on HSV-1/KOS.Its 50% cell degeneration inhibition concentration(CPIE(50)),50% cell lethal concentration(CLE(50))and 50% enzyma inhibition concentration(IC(50)) were 46.0,630,0.2μg/ml respectively,and selection toxicity(ST) was 13.7.But CPIE(50),CLE(50) and ST of positive contrasts Ara A were 14.5,200μg/ml and 13.8 respectively,and both of them are of similarity.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1995年第1期33-36,共4页
Journal of China Pharmaceutical University
关键词
鸡血藤
抗病毒
艾滋病毒
逆转录酶
Spatholobus suberectus
antivirus
HIV reverse transcriptase
