摘要
目的探讨存活素(Survivin)和Livin蛋白在脑胶质瘤的表达情况及其与肿瘤恶性程度之间的相互关系。方法应用免疫组织化学方法检测72例脑胶质瘤标本Survivin及Livin蛋白的表达强度、阳性细胞百分比及其与胶质瘤组织学分级之间的关系。结果 Survivin及Livin蛋白表达阳性染色主要位于脑胶质瘤细胞的胞浆,并与脑胶质瘤的组织学分级相关,各级之间差异有统计学意义(P<0.05),随着脑胶质瘤恶性程度增高,Survivin与Livin的表达强度和阳性细胞百分比也随之逐渐增加,且两者表达呈正相关(r=0.353,P<0.01)。结论 Survivin和Livin蛋白在脑胶质瘤呈过度表达,并与脑胶质瘤的恶性程度密切相关,两者的激活在胶质瘤的发生发展过程中可能起协同作用。
Objective To investigate the expression and significance of Survivin and Livin in brain glioma.Methods The expression of Survivin and Livin in 72 patients with brain glioma were detected by immunohistochemical technique.The relationship between the expression of Survivin and Livin and the histological grades was analyzed.Results Survivin and Livin was over-expressed in gliomas and the expression levels were related to the histological grades of gliomas,and the expression levels of Survivin and Livin in the gliomas with higher malignancy were significantly increased（P〈0.05）,and there was significant difference between the expression of Survivin and Livin in the gliomas of different grades,and the expression of Survivin was positively related with that of Livin（r=0.353,P〈0.01）.Conclusion Survivin and Livin is over-expressed in gliomas,which is related to the malignancy of the tumor,there may be some correlations between their activation.
出处
《河北医药》
CAS
2010年第11期1367-1369,共3页
Hebei Medical Journal
