期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

凋亡抑制蛋白Livin:抗癌新靶点 被引量：10

Inhibitor of apoptosis protein Livin:Novel anticancer target
暂未订购
导出
摘要 Livin,又称ML-IAP或KIAP是与肿瘤发生发展密切相关的凋亡抑制蛋白家族(inhibitor of apoposis proteins,IAPs)中的新成员,能够与内源IAP抑制剂SMAC和caspase-3,caspase-7,caspase-9结合,发挥抗细胞凋亡的作用。它特异性高表达于肿瘤组织而使肿瘤组织对放化疗作用变得耐受。近来,体内外研究表明下调或抑制Livin基因表达增加了肿瘤细胞凋亡率,抑制肿瘤细胞的增殖和集落形成能力,提高肿瘤细胞对化疗药物和放疗的敏感性。Livin将成为肿瘤治疗的潜在靶点。 Livin,also called melanoma inhibitor of apoptosis protein（IAP） or kidney IAP,is a novel member of the IAP family which relates with tumor development and progression. It could bind the endogenous IAP antagonist SMAC and caspase- 3, caspase -7, and caspase -9 to inhibit apoptosis. Livin is selectively expressed in the most common human neoplasms and appears to be involved in tumor cell resistance to chemotherapeutic agents and radiotherapy. Several studies in vitro and in vivo have demonstrated that down - regulation or inhibition of Livin expression increases the apoptotic rate, reduces tumor growth potential and sensitized tumor ceils to chemotherapeutic drugs and radiotherapy. Livin will be a new target for cancer treatment.
作者 梁春艳 马萍
机构地区 中国医科大学附属第一医院肿瘤研究所第二研究室
出处 《现代肿瘤医学》 CAS 2008年第6期1055-1058,共4页 Journal of Modern Oncology
基金 辽宁省教委科研项目基金(编号:05L506)
关键词 LIVIN 细胞凋亡 肿瘤治疗 livin apoptosis cancer therapy
分类号 R730.3 [医药卫生—肿瘤]
  • 相关文献

参考文献24

  • 1Salvesen GS, Duckett CS. IAP proteins : blocking the road to death's door [J]. Nat Rev Mol Cell Biol,2002,3(6) :401 -410.
  • 2Kasof GM, Gomes BC. Livin, a novel inhibitor of apoptosis protein family member[ J ]. Biol Chem,2001,276 ( 5 ) :3238 - 3246.
  • 3Crnkovic - Mertens I, Hoppe - Seyler F, Butz K. Induction of apoptosis in tumor cells by siRNA Mediated silencing of the livin/ML - IAP/KIAP gene [ J ] . Oncol,2003,22 (51 ) : 8330 - 8336.
  • 4Crnkovic - Mertens I, Semzow J, Hoppe - Seyler F, et al . Isoform - specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells[ J]. Mol Med,2006,84(3 ) : 232 - 240.
  • 5孙建国,廖荣霞,陈正堂,王志新,张青,胡义德.Livin异构体特异性基因沉默诱导肺腺癌SPC-A1细胞凋亡[J].中国癌症杂志,2005,15(6):505-509. 被引量：11
  • 6Lin JH, Deng G, Huang Q, et al. KIAP, a novel member of the inhibitor of apoptosis protein family [ J]. Biochem Biophys Res Cornmien ,2000,279 (3) :820 - 831.
  • 7Vucic D,Stennicke HR,Pisabarro MT, et al. ML-IAP,a novel inhibitor of apoptosis that is preferentially expressed in human melanomas [ J ]. Cttrr Biol,2000,10 (21 ) : 1359 - 1366.
  • 8Ashhab Y, Alian A, PoHiaek A, et al, Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern [ J ], FEBS Lett, 2001,495 ( 1 - 2 ) : 56 -60,
  • 9T anabe H, Yagihashi A, Tsuji N, et al. Expression of survivin and livin mRNA in non - small - cell lung cancer [ J ]. Lung Cancer, 2004,46(3 ) :299 - 304.
  • 10Yagihashi A, Olunura T, Asanuma K, et al. Detection of autoantibodies to surviving and livin in sera from patients with breast cancer[ J ]. Lung Cancer,2005,362 ( 1 - 2 ) : 125 - 130.

二级参考文献11

  • 1孙建国,廖荣霞,陈正堂,王志新,张青,伍伟玲.一种新的凋亡抑制蛋白Livin在非小细胞肺癌组织中的表达[J].重庆医学,2004,33(7):982-984. 被引量：47
  • 2孙建国,廖荣霞,陈正堂,王志新,张青,胡义德,王东林,粟永萍.Livin异构体特异性siRNA表达载体的构建及其在SPC-A1细胞中的稳定表达[J].肿瘤,2006,26(2):139-143. 被引量：13
  • 3Lin JH ,Deng G,Huang Q,et al.KIAP,a novel member of the inhibitor of apoptosis protein family[J].Biochem Biophys Res Commun,2000,279(3) :820-831.
  • 4Kasof GM,Gomes BC.Livin,a novel inhibitor of apoptosis protein family member[J].J Biol Chem,2001,276(5) :3238-3246.
  • 5Ashhab Y,Alian A,Polliack A,et al.Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern [J].FEBS Lett,2001,495 (1-2):56-60.
  • 6Vucic D,Stennicke HR,Pisabarro MT,et al.ML-IAP,a novel inhibitor of apoptosis that is preferentially expressed in human melanomas[J].Curr Biol,2000 ,10(21) :1359-1366.
  • 7Yagihashi A,Asanuma K,Tsuji N,et al.Detection of anti-livin antibody in gastrointestinal cancer patients [J].Clin Chem,2003,49(7) :1206-1208.
  • 8Gazzaniga P,Gradilone A,Giuliani L,et al.Expression and prognostic significance of LIVIN,SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer[J].Ann Oncol,2003,14(1) :85-90.
  • 9Tanabe H,Yagihashi A,Tsuji N,et al.Expression of survivin mRNA and livin mRNA in non-small-cell lung cancer [J].Lung Cancer,2004,46 (3) :299-304.
  • 10Crnkovic-Mertens I,Hoppe-Seyler F,Butz K.Induction of apoptosis in tumor cells by siRNA-mediated silencing of the Livin/M L-IAP/KIAP gene [J].Oncogene,2003,22 (51):8330-8336.

共引文献10

同被引文献60

引证文献10

二级引证文献30

现代肿瘤医学
2008年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部