摘要
目的:观察康艾注射液联合紫杉醇和顺铂治疗晚期非小细胞肺癌(NSCLC)的临床疗效和不良反应。方法:60例中晚期NSCLC患者随机分为治疗组(康艾注射液联合化疗组)30例和对照组(单纯化疗组)30例,评价2组患者化疗2个疗程后有效率、化疗期间及化疗后不良反应及生存质量的改善情况。结果:治疗组有效率优于对照组,但差异未达统计学意义(P>0.05)。治疗组不良反应在胃肠道反应、骨髓抑制、脱发及疲劳方面均低于对照组,差异有统计学意义(P<0.05)。治疗组生存质量改善,卡氏评分提高,改善率达到59.2%,两组比较差异有统计学意义(P<0.05)。结论:康艾注射液联合TP方案治疗非小细胞肺癌有较好疗效,能有效减轻化疗的不良反应,提高生存质量。
Objective：To observe the efficacy and adverse reactions of Kangai injection plus paclitaxel and cisplatin in the treatment of advanced non - small cell lung cancer（NSCLC）. Methods： Sixty cases with advanced NSCLC were randomly divided into two groups ,30 patients of test group were treated with Kangai injection combined with TP, 30 patients of control group were only treated with TP. The chemotherapy effect, side effects and improvement of the quality of llfe of two groups were evaluated during and after chemotherapy. Results： The chemotherapy effect of test group was higher than the other,but the difference was not statistically significant （P 〉 0.05 ）. The toxicity reactions of test group in gastrointestinal tract, bone marrow suppression, alopecia and fatigue were lower than in the control group ,the difference was statistically significant （P 〈 0.05 ）, the quality of life, Karnofsky score in test group increased, improving rate was 59.2% ,the difference was statistically significant（ P 〈 0.05 ）. Conclusion： Kangai in- jection combined with TP in the treatment of non - small cell lung cancer have better efficacy, can effectively reduce toxicity and improve quality of life.
出处
《现代肿瘤医学》
CAS
2010年第6期1132-1134,共3页
Journal of Modern Oncology
关键词
康艾注射液
化疗
晚期非小细胞肺癌
Kangai injection
chemotherapy
non - small cell lung cancer
