摘要
目的：观察中药麦冬的遗传毒性和抗诱变作用。方法：应用小鼠骨髓嗜多染红细胞微核试验（MNT）。结果：各剂量（1．7，3．4，6．8g／kg）麦冬所致的微核率与正常对照组比较无显著性差异（P＞0．05）；麦冬小、中剂量对环磷酰胺（CP）所致的微核率无抑制作用（P＞0．05），但是大剂量（6．8g／kg）对CP所致的微核率有较明显的抑制作用（P＜0．05）。结论：麦冬本身对遗传物质无诱变作用，并在大剂量时，具有抗诱变作用。
Objective: To observe the genetic toxicity and antimutagenic effect of Radix Ophiopogonis.Methods:The micronucleus test of mouse bone marrow cell (MNT) was used. Results: The difference were not significant in rate of micronucleus in mouse bone marrow induced by Radix Ophiopogonis compared with NS group (P>0. 05). Radix Ophiopogonis (1. 7, 3. 4 g/kg) could not decrease micronuclei frequencies induced by CP (P>0' 05),and Radix Ophiopogonis (6.8 g/kg) could significantly inhibit dricronuclei frequencies (P<0.05). Conclusion:The Chinese medicine itself has irc genetoxic effect,and it may be an antimutagen at higher dose level.
出处
《白求恩医科大学学报》
CSCD
1999年第2期129-130,共2页
Journal of Norman Bethune University of Medical Science
基金
国家自然科学基金!39170942
关键词
麦冬
微核试验
环磷酰胺
抗诱变
Radix Ophiopogunis
micronucleus
antimutation
