摘要
目的探讨血管紧张素转换酶（ＡＣＥ）基因插入／缺失（Ｉ／Ｄ）与高血压患者并发脑梗塞的关系。方法应用多聚酶链式反应（ＰＣＲ）方法对原发性高血压（ＥＨ）患者１８２例（其中并发脑梗塞６１例）和对照组５０例正常人的ＡＣＥ基因Ｉ／Ｄ多态性进行检测。结果高血压患者并发脑梗塞组的ＤＤ基因型及Ｄ等位基因频率（０．５２和０．６５）明显高于高血压无伴发脑梗塞组（０．３２和０．４７）和对照组（０．３０和０．４６），高血压无伴发脑梗组与对照组相比差别无显著性。结论ＡＣＥ基因Ｉ／Ｄ多态性与高血压患者脑梗塞有相关性。
Objective\ To analyse angiotensin converting enzyme(ACE) gene polymorphism in essential hypertensive with ischemic stroke . \ Methods\ A 287 bp I/D polymorphism in intron 16 of the ACE gene was examined by polymerase chain reaction in a study of 182 essential hypertension patients(61 case accompanied with ischemic stroke) and 50 control sujects(age,sex matched each other).\ Results\ Polymorphism of the ACE gene was categorized into three genotype: two deletion alleles(genotype DD), heterozygous alleles(genotype ID), and two insertion alleles(genotype II). \ The frequencies of DD genotype and D alleles in essential hypertension with ischemic stroke(0.52 and 0.65) were significantly higher than those in hypertensive patients without ischemic stroke(0.32 and 0.47) and control subjects(0.30 and 0.46). \ Conclusion\ ACE I/D polymorphism is associated with essential hypertension with ischemic stroke.\ D alleles may be an independent risk factor for development of ischemic stroke in hypertensives.
出处
《福建医科大学学报》
1999年第1期41-45,共5页
Journal of Fujian Medical University
基金
福建省卫生厅科研基金
关键词
ACE
基因多态性
高血压
脑梗塞
angiotensin converting enzyme
gene polymorphism
essential hypertension
ischemic storke
