摘要
目的:观察GnRHa触发排卵的临床效果。方法:回顾性分析328例多囊卵巢综合征患者1259个促排卵周期,随机分组,当直径≥16mm卵泡>6个和/或卵巢直径≥6cm,归入试验组,试验组曲普瑞林0.1mg皮下注射,1次/日(n=736周期);对照组绒促性素10000U肌肉注射,1次/日(n=523周期)。比较两组的治疗结果。结果:两组平均年龄、不孕年限、基础内分泌情况、排卵日子宫内膜厚度比较,无统计学差异(P>0.05);两组排卵率、妊娠率、多胎妊娠率比较,无统计学差异(P>0.05),中重度OHSS发生率比较,组间有统计学差异(P<0.05);两组排卵数比较,有统计学差异(P<0.05);优势卵泡个数分层比较,两组排卵率无统计学差异(P>0.05)。结论:0.1mgGnRHa诱发排卵的排卵率、妊娠率与HCG组相似,能有效的降低OHSS发生;但GnRHa诱发排卵组,排卵数多于HCG组,妊娠率及多胎妊娠数与HCG组相似,可能与GnRHa诱发排卵后的黄体缺陷有关。
Objective：To observe the clinical effect of GnRHa in triggering ovulation.Methods：328 patients with polycystic ovary syndrome（1 259 ovulation induction cycles）were analyzed retrospectively and divided into study group and control group randomly,the patients with diameter of follicles≥16 mm,number of follicles6 and/or diameter of ovary≥6 cm were classified as experimental group,then they were injected subcutaneously with triptorelin 0.1 mg,once a day（n=736 cycles）;the patients in control group were injected intramuscularly with chorionic gonadotropin 10 000 U,once a day（n=523 cycles）,the therapeutic effects were compared between the two groups.Results：There was no significant difference in average age,infertility duration,basic endocrine situation,endometrial thickness on the day of ovulation between the two groups（P0.05）;there was no significant difference in ovulation rate,pregnancy rate and multiple pregnancy rate between the two groups（P0.05）;there was significant difference in incidence of middle-severe OHSS and number of ovulation between the two groups（P0.05）;there was no significant difference in ovulation rate in hierarchical comparison of the number of dominant follicles between the two groups（P0.05）.Conclusion：The ovulation rate and pregnancy rate in ovulation induced by 0.1 mg GnRHa are similar to those in HCG group,which can reduce the occurrence of OHSS effectively;but in GnRHa-induced ovulation group,the number of ovulation is higher than that in HCG group,pregnancy rate and multiple pregnancy rate are similar to those in HCG group,which are related to corpus luteum insufficiency after ovulation induced by GnRHa probably.
出处
《中国妇幼保健》
CAS
北大核心
2010年第16期2235-2237,共3页
Maternal and Child Health Care of China
基金
河北省卫生厅科学技术跟踪项目(GL200826)
