摘要
目的:探讨加减抵当汤对胰岛素抵抗大鼠肝脏组织PAI-1 mRNA表达的影响。方法:造模大鼠随机分成正常组、模型组、加减抵当汤高、中、低剂量组、罗格列酮组,用RT-PCR方法检测加减抵当汤对胰岛素抵抗大鼠肝脏组织PAI-1 mRNA表达的影响。结果:加减抵当汤高、中剂量组能明显下调胰岛素抵抗大鼠PAI-1 mRNA的表达(P<0.05和P<0.01)。结论:加减抵当汤能下调PAI-1 mRNA的表达,可能是其改善胰岛素抵抗的机理之一。
Objective：To explore the effect of modified Didang decoction on PAI-1 gene ex-pression in liver in insulin resistance rats.Methods：The insulin resistance rats were randomly divided into the control group,the model control group,the high,medium and low dosage of modified Didang decoction groups and western medicine （rosiglitazone） control group.Reverse transcriptase polymerase chain reactionwas used to observe the effect of modified Didang decoction on the PAI-1 of liver in rats.Results：Interving groups of modified Didang decoction compared with the model group ,the expression of PAI-1 mRNA in liver were reduced to varying degrees,which medium-dose group was significantly lower （P〈0.01）,followed by high-dose group（P〈0.05）.Conclusion：Through down-regulation on PAI-1 gene expression is possibly one of the mechanisms of modified Didang decoction in treating insulin resistance.
出处
《中华中医药学刊》
CAS
2010年第6期1244-1246,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药管理局资助项目(2007CA006)
