摘要
利用β－环糊精－１，２－二溴乙烷乙醇混合体系作增敏剂首次提出了用荧光光度法测量阿苯达唑含量的方法。详细讨论了协同剂对β－环糊精增敏作用的影响，根据不同酸度条件下协同剂的用量推断出阿苯达唑、β－环糊精及１，２－二溴乙烷相互存在多种包结形式。当协同剂用量不同时包结程度不同，分别形成１∶１∶１或１∶１∶２的多种包结物。利用本法测定了肠虫清片剂中的有效成分阿苯达唑的含量，结果满意。
A fluorometric method for the determination of albendazole in acid or alkali medium has been proposed. The effect of organic solvent on fluorescence intensity of albendazole in the presence of β cyclodextrin(β CD ) was investigated in detail. The mechanism of fluorescence enhancement by organic solvent for albendazole in the presence of β cyclodextrin was discussed. It has been used for the determination of albendazole in tablet with satisfactory results.
出处
《分析试验室》
CAS
CSCD
1999年第1期83-86,共4页
Chinese Journal of Analysis Laboratory
基金
国家自然科学基金
关键词
阿苯达唑
荧光光度法
肠虫清
测定
Albendazole
β cyclodextrin(β CD)
1,2 Dibromoethane
Fluorimetry
