摘要
目的为验证碱性成纤维细胞生长因子（bFGF）对爆震性耳聋的防治作用。方法选用豚鼠35只，分为4组：bFCF肌注治疗组（10只），震后即刻给予bFGF肌注（50IU／100g）连用4周，生理盐水肌注治疗组（10只），疗程同前；bFGF肌注预防组（10只），生理盐水肌注预防组（5只），剂量同治疗组连用2周。动物爆震100发，每秒1发，脉宽0．5ms，压力峰值172．0dBSPL，爆震前后测定ABR阈值。最后处死动物做耳蜗SDH染色铺片，观察耳蜗损伤情况。结果震前肌注bFGF预防组动物阈移比生理盐水组要轻，但统计学差异不明显。耳蜗病损区域集中于一回上至二回下，细胞界线不清，SDH染色变浅。震后bFGF肌注治疗组动物震后阈移恢复较其它组快，铺片见耳蜗病变为外毛细胞节段性缺失，散在性内毛细胞缺失，病变范围从基底膜钩端至第三回下半。结论震前肌注bFGF对预防耳蜗病变从形态学上观察有一定作用；动物震后即刻bFGF肌注治疗对阈移恢复有明显作用。
Objective To test the effecte of bFGF on prevention and treament of blast-induced hearingloss. Methods thirty - five guinea pigs were divided into four groups: the treatment groups - bFGF intramuscu-lar injection(10)and normal saline(N. S) intramuscular injection(10), the prevention groups - bFGF intramuscu-lar injection(10)and N. S intramuscular injechon(5). Using the ABR to measure the threshold before and after ex-posure(172.0 dB SPL 100 rounds),and before and after bFGF injechon. Results The threshold shift after ex-posure. In prevention group,bFCF intramuscular injection before exposure could reduce the damage range in thecochlea. Conclusion The bFCF may be used for prevention to blast - induced hearing loss in clinics.
出处
《听力学及言语疾病杂志》
CAS
CSCD
1999年第1期8-10,共3页
Journal of Audiology and Speech Pathology
基金
留学回国人员科研启动基金
全军指令课题
关键词
爆震伤
耳蜗
耳聋
防治
BFGF
Basic fibroblast growth factor
Blast injuries
Cochlea
Treatment
