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布托啡诺复合靶控输注异丙酚诱导对血流动力学及靶浓度的影响 被引量：5

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摘要 目的观察靶控输注(TCI)异丙酚诱导中,维持脑电双频指数(BIS)为55±5时,复合不同剂量的布托啡诺对异丙酚靶浓度及血流动力学的影响。方法择期全麻手术患者80例,ASAⅠ或Ⅱ级,年龄18～65岁,随机分为4组(n=20):Ⅰ、Ⅱ、Ⅲ、Ⅳ组为不同剂量布托啡诺。麻醉诱导:异丙酚起始靶浓度(CP)为3.0μg/mL,每30s以0.3μg/mL浓度递增,至患者意识消失,且BIS在55±5左右时给予布托啡诺30μg/kg(Ⅰ组)、40μg/kg(Ⅱ组)、50μg/kg(Ⅲ组)、60μg/kg(Ⅳ组),维持予先设定的BIS不变,根据BIS调整异丙酚靶浓度以0.3μg/mL浓度递增或递减。BIS稳定后再静脉注射维库溴铵0.12mg/kg,肌松满意后行气管插管。记录麻醉前3min(T0)、BIS为55±5左右时给阿片类药前即刻(T1)、给阿片类药BIS稳定后(T2)、插管前即刻(T3)、插管后即刻(T4)、插管后3mim(T5)、6mim(T6)各时间点CP、HR、MAP及BIS。结果各组T0、T1时刻CP、HR、MAP及BIS差异无统计学意义(P>0.05);与Ⅰ组比较,Ⅱ、Ⅲ、Ⅳ组在T2至T6时刻CP明显降低(P<0.05)。Ⅰ组在T4至T6时刻HR、MAP上升明显(P<0.05),而Ⅱ、Ⅲ、Ⅳ组无明显变化(P>0.05)。结论 TCI异丙酚诱导时,以BIS降至55±5为指标,静脉注射布托啡诺可进一步降低异丙酚的血浆及效应室靶浓度;可减轻异丙酚诱导时所导致HR减慢和MAP下降,静脉注射40～60μg/kg布托啡诺具有较好的镇静作用,可较好地抑制气管插管反应。
作者 陈恭达 夏瑞 尹泓 陈益 迟晓慧 田玉科 罗爱林
机构地区 湖北省荆州市第一人民医院麻醉科 华中科技大学同济医学院附属同济医院麻醉科
出处 《广东医学》 CAS CSCD 北大核心 2010年第10期1281-1283,共3页 Guangdong Medical Journal
关键词 布托啡诺 异丙酚 靶控输注 脑电双频谱指数 血液动力学
分类号 R614.24 [医药卫生—麻醉学]
  • 相关文献

参考文献13

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二级参考文献19

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共引文献84

同被引文献25

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  • 9孔晓东,张鑫,王丹一.瑞芬太尼复合异丙酚持续泵注与芬太尼复合异氟醚在腹腔镜胆囊切除术的比较[J].当代医学,2011,17(1):106-107. 被引量：19
  • 10林赛娟,黄文思,田毅,朱坚忠.舒芬太尼或芬太尼复合丙泊酚麻醉在内镜逆行胰胆管造影术的比较[J].海南医学院学报,2011,17(1):128-130. 被引量：11

引证文献5

二级引证文献19

广东医学
2010年 第10期

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